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\u56fe\u7247\u6765\u6e90\uff1aI, DavidShankbone, CC BY-SA 3.0<\/span><\/figcaption><\/figure>\n<\/div>\n\n\n
\u4ee5\u540e\u6389\u4e86\u7684\u7259\uff0c\u8bf4\u4e0d\u5b9a\u8fd8\u80fd\u91cd\u65b0\u957f\u51fa\u6765\uff01<\/section>\n\n\n\n
\u64b0\u6587 | \u51ac\u9e22
\u5ba1\u6821 | \u9ec4\u96e8\u4f73

<\/strong>\n\n\n\n

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\u6b63\u5728\u6362\u7259\u7684\u5c0f\u5b69\uff08\u56fe\u7247\u6765\u6e90\uff1aBy Loadmaster (David R. Tribble) CC BY-SA 3.0\uff09<\/span><\/figcaption><\/figure>\n<\/div>\n\n\n

\u76ee\u524d\u56e0\u4e3a\u5404\u79cd\u95ee\u9898\u800c\u7f3a\u5931\u7259\u9f7f\u7684\u4eba\uff0c\u53ea\u80fd\u901a\u8fc7\u5047\u7259\u3001\u79cd\u690d\u7259\u7b49\u65b9\u6cd5\u6765\u6cbb\u7597\u548c\u5f25\u8865\uff0c\u4f46\u6700\u8fd1\u65e5\u672c\u79d1\u5b66\u5bb6\u5f00\u53d1\u7684\u4e00\u79cd\u65b0\u836f\u7269\uff0c\u6709\u671b\u8ba9\u7f3a\u5931\u7259\u9f7f\u7684\u60a3\u8005\u76f4\u63a5\u957f\u51fa\u65b0\u7259\u9f7f<\/strong>\u3002<\/p>\n\n\n\n



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\u4eba\u7684\u7259\u9f7f\u7ec4\u6210\uff08\u56fe\u7247\u6765\u6e90\uff1awikimedia\uff09<\/span><\/figcaption><\/figure>\n<\/div>\n\n\n

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2005\u5e74\u5de6\u53f3\uff0c\u9ad8\u6865\u56de\u5230\u65e5\u672c\uff0c\u5728\u4eac\u90fd\u5927\u5b66\u7ee7\u7eed\u4ed6\u7684\u7814\u7a76\u3002\u5f88\u5feb\uff0c\u4ed6\u4f3c\u4e4e\u5728\u4e00\u7c7b\u4e0e\u7259\u9f7f\u7f3a\u5931\u76f8\u53cd\u7684\u75be\u75c5\u4e2d\u627e\u5230\u4e86\u7b54\u6848\uff1a\u4e00\u4e9b\u4eba\u7c7b\u548c\u54fa\u4e73\u52a8\u7269\u4f1a\u6bd4\u6b63\u5e38\u60c5\u51b5\u957f\u51fa\u66f4\u591a\u7684\u7259<\/strong>\uff0c\u5373\u201c\u7259\u8fc7\u591a\u201d\uff08hyperdontia\uff09\uff0c\u5b83\u53ef\u80fd\u7531\u67d0\u79cd\u57fa\u56e0\u7f3a\u9677\u5f15\u8d77\u3002<\/p>\n\n\n

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\u201c\u7259\u8fc7\u591a\u201d\u60a3\u8005\uff08\u56fe\u7247\u6765\u6e90\uff1aTakahashi et al, 2013\uff09<\/span><\/figcaption><\/figure>\n<\/div>\n\n\n

\u6b64\u524d\u6709\u7814\u7a76\u8005\u53d1\u73b0\uff0c\u7f3a\u4e4f\u5408\u6210USAG-1\u86cb\u767d\u7684\u57fa\u56e0\u7684\u5c0f\u9f20\uff0c\u7259\u9f7f\u7684\u6570\u91cf\u4f1a\u589e\u52a0<\/strong>\u3002\u800c\u9ad8\u6865\u7684\u7814\u7a76\u56e2\u961f\u901a\u8fc7\u591a\u5e74\u7684\u7814\u7a76\uff0c\u7406\u6e05\u4e86\u5176\u4e2d\u7684\u673a\u5236\u3002\u4ed6\u4eec\u8ba4\u4e3a\uff0c\u8bb8\u591a\u201c\u7259\u8fc7\u591a\u201d\u60a3\u8005\uff0c\u591a\u51fa\u7684\u7259\u53ef\u80fd\u6765\u6e90\u4e8e\u4eba\u7c7b\u7684\u201c\u7b2c\u4e09\u7259\u5217\u201d\uff08third dentition\uff09<\/strong>\u3002<\/p>\n\n\n\n

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\u4eba\u548c\u5c0f\u9f20\u8fd8\u6709\u957f\u51fa\u989d\u5916\u7259\u5217\u7684\u6f5c\u529b\uff08\u56fe\u7247\u6765\u6e90\uff1aTakahashi et al, 2020\uff09<\/span><\/figcaption><\/figure>\n<\/div>\n\n\n

\u800cUSAG-1\u86cb\u767d\u7684\u529f\u80fd\uff0c\u6070\u597d\u662f\u6291\u5236\u201c\u7b2c\u4e09\u7259\u5217\u201d\u7684\u751f\u957f<\/strong>\uff0c\u5b83\u53ef\u4ee5\u6291\u5236\u5728\u7259\u9f7f\u53d1\u80b2\u8fc7\u7a0b\u4e2d\u4e24\u79cd\u81f3\u5173\u91cd\u8981\u7684\u86cb\u767d\u8d28\uff1a\u9aa8\u5f62\u6001\u53d1\u751f\u86cb\u767d\uff08BMP\uff09\u548cWnt\u3002\u800c\u90a3\u4e9b\u51fa\u73b0\u201c\u7259\u8fc7\u591a\u201d\u75c7\u72b6\u7684\u4eba\u6216\u5c0f\u9f20\uff0c\u5f88\u591a\u6b63\u662f\u7531\u4e8e\u7f16\u7801USAG-1\u7684\u57fa\u56e0\u5b58\u5728\u7f3a\u9677\uff0cBMP\u548cWnt\u4fe1\u53f7\u6ca1\u80fd\u88ab\u6709\u6548\u6291\u5236\uff0c\u90e8\u5206\u5c5e\u4e8e\u65b0\u7259\u5217\u7684\u7259\u9f7f\u957f\u4e86\u51fa\u6765<\/strong>\u3002<\/p>\n\n\n

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\u901a\u8fc7\u6291\u5236USAG-1\u529f\u80fd\u8ba9\u7f3a\u7259\u60a3\u8005\u957f\u7259\u7684\u601d\u8def\uff08\u56fe\u7247\u6765\u6e90\uff1aTakahashi et al, 2020\uff09<\/span><\/figcaption><\/figure>\n<\/div>\n\n\n

\u9ad8\u6865\u610f\u8bc6\u5230\uff0c\u5982\u679c\u80fd\u4eba\u4e3a\u5730\u9776\u5411\u963b\u65adUSAG-1\u86cb\u767d\u7684\u529f\u80fd\uff0c\u662f\u4e0d\u662f\u5c31\u6709\u673a\u4f1a\u8ba9\u7f3a\u5931\u7259\u9f7f\u7684\u4eba\uff0c\u518d\u957f\u51fa\u7259\u9f7f\u5462\uff1f\u4e8e\u662f\uff0c\u57282018\u5e74\u53d1\u8868\u4e8e\u300a\u79d1\u5b66\u00b7\u8fdb\u5c55\u300b\uff08Science Advances<\/em>\uff09\u7684\u7814\u7a76\u4e2d\uff0c\u9ad8\u6865\u56e2\u961f\u6210\u529f\u7814\u5236\u51fa\u4e86\u4e00\u79cd\u53ef\u4ee5\u6291\u5236USAG-1\u4e0eBMP\u7ed3\u5408\u7684\u4e2d\u548c\u6297\u4f53\uff0c\u5e76\u6210\u529f\u8ba9\u5c0f\u9f20\u548c\u96ea\u8c82\u957f\u51fa\u4e86\u6b63\u5e38\u5f62\u6001\u7684\u7259\u9f7f\uff0c\u4e14\u6ca1\u6709\u53d1\u73b0\u526f\u4f5c\u7528<\/strong>\u3002<\/p>\n\n\n

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\u957f\u51fa\u65b0\u7259\u7684\u96ea\u8c82\uff08\u56fe\u7247\u6765\u6e90\uff1aTakahashi et al, 2018\uff09<\/span><\/figcaption><\/figure>\n<\/div>\n\n\n

\u800c\u73b0\u5728\uff0c\u4ed6\u4eec\u5df2\u7ecf\u636e\u6b64\u8fdb\u4e00\u6b65\u7814\u5236\u51fa\u4e86\u51c6\u5907\u7528\u4e8e\u4eba\u7684\u957f\u7259\u836f\u7269TR035<\/strong>\uff0c\u73b0\u5df2\u901a\u8fc7\u65e5\u672c\u76f8\u5173\u673a\u6784\u7684\u6279\u51c6\uff0c\u5c06\u4e8e2024\u5e749\u6708\u52302025\u5e748\u6708\u671f\u95f4\u5f00\u5c55I\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002\u4ed6\u4eec\u5c06\u62db\u52df30\u81f365\u5c81\u7684\u6709\u4e00\u9897\u6216\u591a\u9897\u81fc\u9f7f\u7f3a\u5931\u7684\u7537\u6027\uff0c\u8fdb\u884c\u5355\u5242\u91cf\u3001\u53cc\u76f2\u7684\u5b89\u6170\u5242\u5bf9\u7167\u7ec4\u8bd5\u9a8c\uff0c\u4ee5\u786e\u8ba4\u8be5\u836f\u7269\u7684\u5b89\u5168\u6027\u3002\u63a5\u4e0b\u6765\uff0c\u4ed6\u4eec\u5c06\u62db\u52df\u5e74\u9f84\u57282\u52307\u5c81\u4e4b\u95f4\uff0c\u67094\u9897\u6216\u66f4\u591a\u5148\u5929\u6027\u7f3a\u5931\u7259\u9f7f\u7684\u60a3\u8005\uff0c\u7528\u4ee5\u63a2\u7a76\u8be5\u836f\u7269\u7684\u6548\u679c\u3002<\/p>\n\n\n

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\u7814\u7a76\u8fdb\u5c55\uff08\u56fe\u7247\u6765\u6e90\uff1aRavi et al, 2023\uff09<\/span><\/figcaption><\/figure>\n<\/div>\n\n\n

\u636e\u300a\u6bcf\u65e5\u65b0\u95fb\u300b\u62a5\u9053\uff0c\u7814\u7a76\u56e2\u961f\u76f8\u4fe1\uff0c\u8fd9\u79cd\u836f\u7269\u672a\u6765\u4e0d\u4ec5\u80fd\u5e2e\u52a9\u5148\u5929\u7f3a\u7259\u7684\u4eba\u957f\u51fa\u7259\u9f7f\uff0c\u8fd8\u80fd\u5e2e\u52a9\u90a3\u4e9b\u56e0\u4e3a\u86c0\u7259\u6216\u53d7\u4f24\u800c\u5931\u53bb\u7259\u9f7f\u7684\u4eba\u91cd\u65b0\u957f\u51fa\u7259\u9f7f<\/strong>\u3002\u6839\u636e\u8ba1\u5212\uff0c\u8be5\u836f\u7269\u6709\u671b\u57282030\u5e74\u5f00\u59cb\u4e0a\u5e02\u9500\u552e\u3002<\/p>\n\n\n\n

\u5e0c\u671b\u5b83\u5c06\u6765\u80fd\u5e2e\u5230\u8bb8\u591a\u4eba\u5427\u3002\u6216\u8bb8\u7b49\u6211\u8001\u4e86\uff0c\u5c31\u4e0d\u7528\u518d\u7fa1\u6155\u9ca8\u9c7c\u4e86\u3002<\/p>\n\n\n\n
\u53c2\u8003\u94fe\u63a5\uff1a
https:\/\/www.kitano-hp.or.jp\/info\/20240503
https:\/\/www.kitano-hp.or.jp\/section\/dental\/clinical-trial
https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2352320423000044
https:\/\/inflammregen.biomedcentral.com\/articles\/10.1186\/s41232-020-00130-x
https:\/\/mainichi.jp\/english\/articles\/20230609\/p2a\/00m\/0sc\/026000c
https:\/\/mainichi.jp\/english\/articles\/20240503\/p2a\/00m\/0sc\/012000c
https:\/\/www.intechopen.com\/chapters\/43101
https:\/\/www.science.org\/doi\/10.1126\/sciadv.abf1798#elettersSection
https:\/\/journals.sagepub.com\/doi\/10.1177\/0022034519858282
https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S1084952113001420
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