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20\u4e16\u7eaa50\u5e74\u4ee3\uff0c\u5b89\u5fb7\u9c81\u00b7\u6c99\u5229\uff08Andrew Schally\uff09\u4e0e\u7f57\u6b47\u00b7\u5409\u8036\u66fc\uff08Roger Guillemin\uff09\u5404\u81ea\u5728\u81ea\u5df1\u7684\u5b9e\u9a8c\u5ba4\u91cc\uff0c\u5206\u522b\u4ece\u732a\u548c\u7ef5\u7f8a\u7684\u4e0b\u4e18\u8111\u4e2d\u63d0\u53d6\u51fa\u4e86\u4e00\u4e9b\u5316\u5408\u7269\u3002\u4ed6\u4eec\u53d1\u73b0\u5982\u679c\u628a\u8fd9\u4e9b\u5316\u5408\u7269\u4f5c\u7528\u4e8e\u5782\u4f53\u7ec4\u7ec7\uff0c\u5782\u4f53\u5c31\u4f1a\u91ca\u653e\u51fa\u67d0\u4e9b\u6fc0\u7d20\u3002<\/p>\n\n\n\n

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GnRH\u5728\u5927\u8111\u4e0b\u4e18\u8111\u4e2d\u4ea7\u751f\uff0c\u662f\u753110\u4e2a\u6c28\u57fa\u9178\u7ec4\u6210\u7684\u80bd\u7c7b\u6fc0\u7d20\u3002\u5b83\u5728\u91ca\u653e\u65f6\uff0c\u4f1a\u89e6\u53d1\u5782\u4f53\u5206\u6ccc\u66f4\u591a\u9ec4\u4f53\u751f\u6210\u7d20\u548c\u5375\u6ce1\u523a\u6fc0\u7d20\uff0c\u4ece\u800c\u63a8\u52a8\u6027\u53d1\u80b2\u3002\u968f\u7740GnRH\u7684\u53d1\u73b0\uff0c\u7814\u7a76\u4eba\u5458\u5f00\u59cb\u5bf9\u5176\u5e94\u7528\u4ea7\u751f\u4e86\u6d53\u539a\u5174\u8da3\uff0c\u800c1978\u5e74\u7684\u4e00\u9879\u5f00\u521b\u6027\u7814\u7a76\u66f4\u662f\u6539\u53d8\u4e86GnRH\u7c7b\u4f3c\u7269\u5728\u4e34\u5e8a\u4e0a\u7684\u5e94\u7528<\/strong>\u3002<\/p>\n\n\n

\n
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\u56fe\u7247\u6765\u6e90\uff1apixabay<\/span><\/figcaption><\/figure>\n<\/div>\n\n\n

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1981\u5e74\u665a\u4e9b\u65f6\u5019\uff0c\u300a\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\u300b\uff08New England Journal of Medicine<\/em>\uff09\u53d1\u8868\u4e86\u4e00\u7bc7\u91cc\u7a0b\u7891\u5f0f\u8bba\u6587\uff0c\u62a5\u9053\u4e86\u5bf95\u540d\u60a3\u6709\u4e2d\u67a2\u6027\u6027\u65e9\u719f\u7684\u5973\u5b69\u4f7f\u7528\u957f\u6548GnRHa\u2014\u2014\u4eae\u4e19\u745e\u6797\uff08leuprolide\uff09\u7684\u6cbb\u7597\u6548\u679c\u3002\u8be5\u836f\u7269\u4ee5\u6bcf\u65e5\u76ae\u4e0b\u6ce8\u5c04\u7684\u5f62\u5f0f\u7ed9\u836f\uff0c\u663e\u8457\u964d\u4f4e\u4e86\u60a3\u8005\u4f53\u5185\u4fc3\u6027\u817a\u6fc0\u7d20\u548c\u96cc\u4e8c\u9187\uff08\u4e00\u79cd\u96cc\u6fc0\u7d20\uff09\u7684\u6c34\u5e73\u3002<\/p>\n\n\n\n

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\u8bca\u65ad\u7684\u529b\u91cf<\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/span><\/mark><\/strong><\/p>\n\n\n\n

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\u53c2\u8003\u94fe\u63a5\uff1a
https:\/\/medium.com\/write-to-inspire\/lina-marcela-medina-de-jurado-the-girl-who-gave-birth-to-her-child-at-the-age-of-5-b65af422a375
https:\/\/karger.com\/hrp\/article\/95\/6\/568\/828525
https:\/\/www.childrenshospital.org\/conditions\/precocious-early-puberty
https:\/\/academic.oup.com\/jcem\/article-abstract\/108\/9\/2282\/7071555
https:\/\/www.nature.com\/articles\/s41588-024-01798-4
https:\/\/www.cam.ac.uk\/research\/news\/largest-ever-genetic-study-of-age-of-puberty-in-girls-shows-links-with-weight-gain
https:\/\/www.scientificamerican.com\/article\/why-are-girls-getting-their-periods-so-young\/
https:\/\/www.nobelprize.org\/prizes\/medicine\/1977\/press-release\/
https:\/\/www.nbcnews.com\/health\/kids-health\/puberty-starting-earlier-treatment-children-rcna125441
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