{"id":1677,"date":"2024-10-10T22:01:00","date_gmt":"2024-10-10T14:01:00","guid":{"rendered":"https:\/\/www.huanqiukexue.com\/?p=1677"},"modified":"2024-12-05T16:50:09","modified_gmt":"2024-12-05T08:50:09","slug":"%e7%8b%ac%e5%ae%b6%e4%b8%93%e8%ae%bf%ef%bc%9aalphafold%e5%b9%b6%e9%9d%9e%e5%94%af%e4%b8%80%e5%87%ba%e8%b7%af-%e6%96%b0%e5%8a%a0%e5%9d%a1%e5%9b%bd%e7%ab%8b%e5%a4%a7%e5%ad%a6%e5%bc%a0%e9%98%b3","status":"publish","type":"post","link":"https:\/\/www.huanqiukexue.com\/?p=1677","title":{"rendered":"\u72ec\u5bb6\u4e13\u8bbf\uff1aAlphaFold\u5e76\u975e\u552f\u4e00\u51fa\u8def | \u65b0\u52a0\u5761\u56fd\u7acb\u5927\u5b66\u5f20\u9633\u6559\u6388\u5bf9\u8c08\u300a\u73af\u7403\u79d1\u5b66\u300b"},"content":{"rendered":"<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1200\" height=\"716\" src=\"https:\/\/www.huanqiukexue.com\/wp-content\/uploads\/2024\/12\/WechatIMG90.jpg\" alt=\"\" class=\"wp-image-1676\" style=\"width:600px\" srcset=\"https:\/\/www.huanqiukexue.com\/wp-content\/uploads\/2024\/12\/WechatIMG90.jpg 1200w, https:\/\/www.huanqiukexue.com\/wp-content\/uploads\/2024\/12\/WechatIMG90-300x179.jpg 300w, https:\/\/www.huanqiukexue.com\/wp-content\/uploads\/2024\/12\/WechatIMG90-1024x611.jpg 1024w, https:\/\/www.huanqiukexue.com\/wp-content\/uploads\/2024\/12\/WechatIMG90-768x458.jpg 768w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption class=\"wp-element-caption\"><span style=\"color: rgb(153, 153, 153); font-size: 16px; letter-spacing: 1px;\">\u56fe\u7247\u6765\u6e90\uff1a\u5f20\u9633<\/span><\/figcaption><\/figure>\n<\/div>\n\n\n<section data-autoskip=\"1\" style=\"overflow: auto; line-height: 2.45; padding: 20px; border-radius: 5px; overflow-wrap: normal; color: rgb(1, 1, 1); background-color: rgb(213, 220, 225);\"><span style=\"letter-spacing: 1px; font-size: 18px;\">2024\u5e74\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956\u9881\u7ed9\u4e86\u8ba1\u7b97\u86cb\u767d\u8d28\u8bbe\u8ba1\u548c\u7ed3\u6784\u9884\u6d4b\u9886\u57df\uff0c\u300a\u73af\u7403\u79d1\u5b66\u300b2024\u5e7410\u6708\u520a\u4e5f\u63a8\u51fa\u4e86\u201cAI\u91cd\u5851\u7ed3\u6784\u751f\u7269\u5b66\u201d\u4e13\u9898\u3002\u8bfa\u5956\u516c\u5e03\u524d\u4e0d\u4e45\uff0c\u6211\u4eec\u72ec\u5bb6\u4e13\u8bbf\u4e86\u8be5\u4e13\u9898\u7684\u5ba1\u6821\u8005\u3001\u65b0\u52a0\u5761\u56fd\u7acb\u5927\u5b66\u8ba1\u7b97\u673a\u79d1\u5b66\u548c\u751f\u7269\u5316\u5b66\u6559\u6388\u4ee5\u53ca\u764c\u75c7\u79d1\u5b66\u7814\u7a76\u6240\u9ad8\u7ea7\u7814\u7a76\u5458\u5f20\u9633\u8001\u5e08\uff0c\u804a\u4e86\u804a\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u9886\u57df\u53d1\u5c55\u53f2\uff0c\u4ee5\u53caAlphaFold\u5bf9\u8be5\u9886\u57df\u7684\u5f71\u54cd\u3002<\/section>\n\n\n\n<strong style=\"color: rgb(153, 153, 153); font-size: 16px; letter-spacing: 1px; line-height: 200%;\"><br>\u672c\u520a\u8bb0\u8005 | \u9ec4\u96e8\u4f73<br><\/strong>\n\n\n\n<p><strong>\u300a\u73af\u7403\u79d1\u5b66\u300b\uff1a<\/strong><\/p>\n\n\n\n<p>\u5f20\u8001\u5e08\u597d\uff01\u9996\u5148\u6709\u8bf7\u5f20\u8001\u5e08\u7b80\u5355\u4ecb\u7ecd\u4e00\u4e0b\u81ea\u5df1\u7684\u7814\u7a76\u80cc\u666f\u3002<\/p>\n\n\n\n<p><strong>\u5f20\u9633\uff08\u65b0\u52a0\u5761\u56fd\u7acb\u5927\u5b66\u6559\u6388\uff09\uff1a<\/strong><\/p>\n\n\n\n<p>\u8c22\u8c22\uff01\u6211\u4eec\u5b9e\u9a8c\u5ba4\u4e3b\u8981\u81f4\u529b\u4e8e<strong>\u4eba\u5de5\u667a\u80fd\uff08AI\uff09\u548c\u8ba1\u7b97\u751f\u7269\u5b66\u7814\u7a76<\/strong>\uff0c\u591a\u5e74\u6765\u4e00\u76f4\u5173\u6ce8\u86cb\u767d\u8d28\u6298\u53e0\u548c\u7ed3\u6784\u9884\u6d4b\u95ee\u9898\uff0c\u4ee5\u53ca\u5b83\u7684\u9006\u95ee\u9898\u2014\u2014\u86cb\u767d\u8d28\u8bbe\u8ba1\u95ee\u9898\u3002\u6700\u8fd1\uff0c\u6211\u4eec\u53c8\u8fdb\u4e00\u6b65\u62d3\u5c55\u4e86\u7814\u7a76\u65b9\u5411\uff0c\u5f00\u59cb\u505aRNA\u548c\u77ed\u80bd\u7684\u8bbe\u8ba1\u4e0e\u7ed3\u6784\u9884\u6d4b\uff0c\u4ee5\u53ca\u63a2\u7d22\u4e0e\u836f\u7269\u8bbe\u8ba1\u76f8\u5173\u7684\u8bfe\u9898\u3002<\/p>\n\n\n\n<p>\u5176\u5b9e\u6211\u4e00\u5f00\u59cb\u5e76\u975e\u8ba1\u7b97\u751f\u7269\u5b66\u65b9\u5411\u3002\u5728\u6211\u672c\u79d1\u3001\u7855\u58eb\u548c\u535a\u58eb\u9636\u6bb5\uff0c\u6211\u7814\u7a76\u7684\u662f<strong>\u7406\u8bba\u7269\u7406\u548c\u7c92\u5b50\u7269\u7406<\/strong>\uff0c\u4e3b\u8981\u5173\u6ce8\u7269\u8d28\u4e16\u754c\u4e2d\u7684\u57fa\u672c\u7c92\u5b50\u53ca\u5176\u76f8\u4e92\u4f5c\u7528\u3002\u76f4\u5230\u6211\u5728\u4e2d\u56fd\u79d1\u5b66\u9662\u505a\u535a\u58eb\u540e\u671f\u95f4\uff0c\u6b27\u9633\u949f\u707f\u9662\u58eb\u4e00\u7bc7\u5173\u4e8e\u7ea2\u7ec6\u80de\u5f62\u72b6\u7684\u8bba\u6587\u5f15\u8d77\u4e86\u6211\u7684\u6781\u5927\u5174\u8da3\uff0c\u8fd9\u624d\u5f00\u59cb\u8f6c\u505a<strong>\u751f\u7269\u7269\u7406<\/strong>\u7814\u7a76\u3002<\/p>\n\n\n\n<p>\u6211\u6700\u521d\u7684\u7814\u7a76\u8bfe\u9898\u662f\u5229\u7528<strong>\u8499\u7279\u5361\u7f57\u65b9\u6cd5<\/strong>\uff08Monte Carlo method\uff09\u6765\u7814\u7a76DNA\u548cRNA\u5206\u5b50\u7684\u5f39\u6027\u5c5e\u6027\uff0c\u5728\u6b64\u8fc7\u7a0b\u4e2d\uff0c\u6211\u4e5f\u63d0\u51fa\u4e86\u4e00\u79cd\u6bd4\u8f83\u65b0\u7684\u8499\u7279\u5361\u7f57\u7b97\u6cd5\u3002\u76f4\u5230\u6211\u5728\u7f8e\u56fd\u79d1\u5b66\u5bb6\u6770\u5f17\u91cc\u00b7\u4ec0\u79d1\u5c14\u5c3c\u514b\uff08Jeffrey Skolnick\uff09\u7684\u5b9e\u9a8c\u5ba4\u505a\u535a\u58eb\u540e\uff0c\u6211\u624d\u5f00\u59cb\u6bd4\u8f83\u6df1\u5165\u5730\u63a5\u89e6\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u95ee\u9898\u3002<\/p>\n\n\n\n<p><strong>\u300a\u73af\u7403\u79d1\u5b66\u300b\uff1a<\/strong><\/p>\n\n\n\n<p>\u5728AlphaFold\u8bde\u751f\u4e4b\u524d\uff0c\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u9886\u57df\u5df2\u7ecf\u5b58\u5728\u4e86\u8bb8\u591a\u5e74\uff0c\u5374\u4e00\u76f4\u672a\u80fd\u53d6\u5f97\u50cfAlphaFold\u8fd9\u6837\u7684\u7a81\u7834\u3002\u6240\u4ee5\u7528\u8ba1\u7b97\u673a\u7b97\u6cd5\u6765\u9884\u6d4b\u86cb\u767d\u8d28\u7ed3\u6784\u4e3a\u4ec0\u4e48\u662f\u4e00\u4ef6\u5f88\u56f0\u96be\u7684\u4e8b\u5462\uff1f<\/p>\n\n\n\n<p><strong>\u5f20\u9633\uff1a<\/strong><\/p>\n\n\n\n<p>\u7528\u8ba1\u7b97\u673a\u9884\u6d4b\u86cb\u767d\u8d28\u7ed3\u6784\u7684\u96be\u70b9\uff0c\u4f53\u73b0\u5728<strong>\u6570\u5b66\u548c\u7269\u7406\u4e24\u4e2a\u65b9\u9762<\/strong>\u3002\u4ece<strong>\u6570\u5b66\u89d2\u5ea6<\/strong>\uff0c\u86cb\u767d\u8d28\u662f\u4e0d\u540c\u6c28\u57fa\u9178\u4e32\u5728\u4e00\u8d77\u7684\u4e00\u7ef4\u957f\u94fe\uff0c\u5b83\u5728\u7ec6\u80de\u73af\u5883\u4e0b\u4f1a\u6298\u53e0\u6210\u4e09\u7ef4\u7ed3\u6784\uff0c\u800c\u5177\u4f53\u6298\u53e0\u6210\u4ec0\u4e48\u7ed3\u6784\uff0c\u53d6\u51b3\u4e8e\u6c28\u57fa\u9178\u5e8f\u5217\u3002<\/p>\n\n\n\n<p>\u4ece<strong>\u7269\u7406\u5b66\u89d2\u5ea6<\/strong>\uff0c\u8981\u89e3\u51b3\u86cb\u767d\u8d28\u6298\u53e0\u548c\u7ed3\u6784\u9884\u6d4b\u95ee\u9898\uff0c\u6211\u4eec\u65e2\u8981\u7406\u89e3\u86cb\u767d\u8d28\u5185\u90e8\u539f\u5b50\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u53c8\u8981\u80fd\u89e3\u51b3\u9ad8\u7ef4\u6784\u8c61\u7a7a\u95f4\u7684\u641c\u7d22\u95ee\u9898\u3002\u5bf9\u4e8e\u524d\u8005\uff0c\u7531\u4e8e\u86cb\u767d\u8d28\u5185\u539f\u5b50\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u5728\u5fae\u89c2\u5c3a\u5ea6\u4e0a\u975e\u5e38\u590d\u6742\uff0c\u56e0\u6b64\u6211\u4eec<strong>\u76ee\u524d\u8fd8\u65e0\u6cd5\u7cbe\u51c6\u63cf\u8ff0\u8fd9\u79cd\u76f8\u4e92\u4f5c\u7528\u7684\u7269\u7406\u5b66\u529b\u573a<\/strong>\u3002\u5bf9\u4e8e\u540e\u8005\uff0c\u7531\u4e8e\u86cb\u767d\u8d28\u53ef\u4ee5\u6709\u5f88\u591a\u79cd\u4e0d\u540c\u6784\u8c61\uff0c<strong>\u8bbe\u8ba1\u4e00\u4e2a\u80fd\u6709\u6548\u641c\u7d22\u5e76\u627e\u5230\u81ea\u7531\u80fd\u6700\u4f4e\u6784\u8c61\u7684\u7b97\u6cd5\u5bf9\u8ba1\u7b97\u673a\u800c\u8a00\u662f\u6781\u5177\u6311\u6218<\/strong><strong>\u7684<\/strong>\u3002<\/p>\n\n\n\n<p>50\u591a\u5e74\u524d\uff0c\u5206\u5b50\u751f\u7269\u5b66\u5bb6\u8d5b\u52d2\u65af\u00b7\u5229\u6587\u7d22\u5c14\uff08Cyrus Levinthal\uff09\u4f30\u8ba1\uff0c\u5982\u679c\u5047\u5b9a\u6bcf\u4e2a\u6c28\u57fa\u9178\u6709\u4e24\u4e2a\u952e\u89d2\uff0c\u5e76\u5047\u5b9a\u6bcf\u4e2a\u952e\u67093\u79cd\u53ef\u80fd\u72b6\u6001\uff0c\u90a3\u4e48\u5bf9\u4e8e\u4e00\u4e2a\u53ea\u6709100\u4e2a\u6c28\u57fa\u9178\uff08\u86cb\u767d\u8d28\u901a\u5e38\u6709\u6570\u767e\u751a\u81f3\u4e0a\u5343\u4e2a\u6c28\u57fa\u9178\uff09\u7684\u6bd4\u8f83\u5c0f\u7684\u86cb\u767d\u8d28\uff0c99\u4e2a\u80bd\u952e\u610f\u5473\u7740\u6700\u591a\u67093<sup>198<\/sup>\u79cd\u4e0d\u540c\u6784\u8c61\uff0c\u7ea6\u7b49\u4e8e10<sup>94<\/sup>\u79cd\u6784\u8c61\u3002\u800c\u6bcf\u4e2a\u6c28\u57fa\u9178\u7684\u89d2\u5ea6\u72b6\u6001\u5b9e\u9645\u8fdc\u4e0d\u6b623\u79cd\uff0c\u6240\u4ee5\u8fd9\u6837\u4e00\u4e2a\u5c0f\u86cb\u767d\u8d28\u7684\u53ef\u80fd\u6784\u8c61\u6570\u76ee\uff0c<strong>\u5df2\u7ecf\u8fdc\u8fdc\u8d85\u8fc7\u6211\u4eec\u53ef\u89c2\u6d4b\u5b87\u5b99\u4e2d\u7684\u539f\u5b50\u603b\u6570<\/strong>\uff08\u76ee\u524d\u4f30\u8ba1\u5927\u7ea6\u662f10<sup>80<\/sup>\uff09\u3002\u5373\u4fbf\u662f\u91cd\u70b9\u641c\u7d22\u76f8\u7a7a\u95f4\u4e2d\u91cd\u8981\u533a\u57df\u7684\u8499\u7279\u5361\u7f57\u65b9\u6cd5\uff0c\u4e5f\u65e0\u6cd5\u5728\u6709\u9650\u65f6\u95f4\u5185\u7a77\u5c3d\u6240\u6709\u53ef\u80fd\u7684\u91cd\u8981\u6784\u8c61\u3002<\/p>\n\n\n\n<p>\u56e0\u6b64\uff0c\u57fa\u4e8e\u7269\u7406\u7684\u4f20\u7edf\u7b97\u6cd5\u5728\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u9886\u57df\u9762\u4e34\u6781\u5927\u56f0\u96be\u3002\u8fd1\u5e74\u6765\uff0cAI\u548c\u6df1\u5ea6\u5b66\u4e60\u6280\u672f\u4e3a\u89e3\u51b3\u8fd9\u4e9b\u95ee\u9898\u63d0\u4f9b\u4e86\u65b0\u7684\u9014\u5f84\u3002<\/p>\n\n\n\n<p><strong>\u300a\u73af\u7403\u79d1\u5b66\u300b\uff1a<\/strong><\/p>\n\n\n\n<p>\u4f5c\u4e3a\u4e00\u4e2a\u53d1\u5c55\u4e86\u51e0\u5341\u5e74\u7684\u9886\u57df\uff0c\u60a8\u80fd\u7b80\u5355\u4ecb\u7ecd\u4e00\u4e0b\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u9886\u57df\u76ee\u524d\u6709\u54ea\u4e9b\u7b97\u6cd5\u5417\uff1f<\/p>\n\n\n\n<p><strong>\u5f20\u9633\uff1a<\/strong><\/p>\n\n\n\n<p>\u5728\u4e0d\u540c\u65f6\u4ee3\uff0c\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u7b97\u6cd5\u6709\u4e0d\u540c\u5206\u7c7b\u3002\u8ba9\u6211\u4eec<strong>\u5c06\u65f6\u95f4\u8f74\u6682\u4e14\u5206\u4e3aAI\u51fa\u73b0\u4e4b\u524d\u548c\u4e4b\u540e<\/strong>\u3002\u5728AI\u51fa\u73b0\u4e4b\u524d\uff0c\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u9886\u57df\u5df2\u7ecf\u6709\u81f3\u5c1150\u5e74\u7684\u53d1\u5c55\u5386\u53f2\u3002\u5728\u8fd9\u534a\u4e2a\u4e16\u7eaa\u4e2d\uff0c\u9010\u6e10\u5f62\u6210\u4e86\u4e24\u7c7b\u4e3b\u8981\u7684\u9884\u6d4b\u7b97\u6cd5\u2014\u2014\u57fa\u4e8e\u7269\u7406\u7684<strong>\u4ece\u5934\u9884\u6d4b<\/strong>\uff08<em>ab initio<\/em>&nbsp;prediction\uff09\u548c<strong>\u57fa\u4e8e\u6a21\u677f\u7684\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u65b9\u6cd5<\/strong>\uff08template-based modeling\uff09\u3002<\/p>\n\n\n\n<p>\u5230\u4e86\u540e\u671f\uff0c\u53c8\u51fa\u73b0\u4e86\u628a\u8fd9\u4e9b\u4e0d\u540c\u7b97\u6cd5\u8fdb\u884c\u878d\u5408\u7684\u7b97\u6cd5\uff0c\u4e5f\u5c31\u662f\u4ee5\u6211\u4eec\u5b9e\u9a8c\u5ba4\u5f00\u53d1\u7684<strong>I-TASSER\u4e3a\u4ee3\u8868\u7684\u7efc<\/strong><strong>\u5408\u7b97\u6cd5<\/strong>\u3002\u8fd9\u79cd\u7b97\u6cd5\u9996\u5148\u4f1a\u4ece\u86cb\u767d\u8d28\u6570\u636e\u5e93\uff08PDB\uff09\u4e2d\u5bfb\u627e\u7ed3\u6784\u6a21\u677f\uff0c\u7136\u540e\u5c06\u8fd9\u4e9b\u6a21\u677f\u8fdb\u884c\u5207\u5272\uff0c\u518d\u5229\u7528\u4ece\u5934\u9884\u6d4b\u7b97\u6cd5\u4e2d\u7684\u7269\u7406\u5b66\u529b\u573a\uff0c\u901a\u8fc7\u8499\u7279\u5361\u7f57\u65b9\u6cd5\u5c06\u8fd9\u4e9b\u7247\u6bb5\u91cd\u65b0\u7ec4\u88c5\uff0c\u6700\u7ec8\u6784\u5efa\u51fa\u5b8c\u6574\u7684\u4e09\u7ef4\u7ed3\u6784\u3002\u7efc\u5408\u7b97\u6cd5\u878d\u5408\u4e86\u4e0d\u540c\u7b97\u6cd5\u7684\u4f18\u52bf\uff0c\u6240\u4ee5\u6bd4\u4f20\u7edf\u5355\u4e00\u7b97\u6cd5\u7684\u9c81\u68d2\u6027\u548c\u7cbe\u5ea6\u66f4\u9ad8\uff0c\u540e\u6765<strong>\u9010\u6e10\u6210\u4e86\u4e3b\u6d41\u7b97\u6cd5<\/strong>\u3002<\/p>\n\n\n\n<p>\u4f46\u662f\uff0c\u5728AI\u51fa\u73b0\u4e4b\u540e\uff0c\u53c8\u6709\u4e86\u4e24\u7c7b\u57fa\u4e8eAI\u7684\u7b97\u6cd5\u3002\u7b2c\u4e00\u7c7b\u8f83\u65e9\u7684\u65b9\u6cd5\u4f1a<strong>\u5148\u4f7f\u7528\u673a\u5668\u5b66\u4e60\u9884\u6d4b\u86cb\u767d\u8d28\u7684\u5c40\u90e8\u6027\u8d28\uff0c\u518d\u4ece\u5c40\u90e8\u7279\u5f81\u8f6c\u6362\u4e3a\u6574\u4f53\u7684\u4e09\u7ef4\u7ed3\u6784<\/strong>\u3002\u4ece\u7b2c\u4e00\u6b65\u8fc7\u6e21\u5230\u7b2c\u4e8c\u6b65\u65f6\uff0c\u5b58\u5728\u4e00\u4e2a\u8f83\u4e3a\u624b\u52a8\u7684\u8fc7\u7a0b\u3002\u5728\u7b2c\u4e8c\u6b65\u4e2d\u7ed3\u6784\u7684\u4f18\u5316\u4f9d\u8d56\u4e8e\u7b97\u6cd5\u7684\u9009\u62e9\uff0c\u4e0d\u5c5e\u4e8eAI\u8303\u7574\u3002<\/p>\n\n\n\n<p>\u800c\u7b2c\u4e8c\u7c7b\u662f\u6240\u8c13\u7684<strong>\u7aef\u5230\u7aef\u9884\u6d4b<\/strong>\uff0c\u5c31\u662f\u7528\u86cb\u767d\u8d28\u7684\u4e00\u7ef4\u5e8f\u5217\u76f4\u63a5\u8bad\u7ec3\u5b66\u4e60\u86cb\u767d\u8d28\u7684\u4e09\u7ef4\u7ed3\u6784\u3002\u8c37\u6b4cDeepMind\u56e2\u961f\u63a8\u51fa\u7684AlphaFold2\u662f\u7b2c\u4e00\u4e2a\u6210\u529f\u5b9e\u73b0\u4e86\u86cb\u767d\u8d28\u7aef\u5230\u7aef\u7ed3\u6784\u9884\u6d4b\u7684\u673a\u5668\u5b66\u4e60\u7b97\u6cd5\u3002\u7531\u4e8e\u7701\u7565\u4e86\u4e2d\u95f4\u6b65\u9aa4\uff0c\u5b8c\u5168\u4f9d\u9760\u6df1\u5ea6\u795e\u7ecf\u7f51\u7edc\u81ea\u52a8\u5b66\u4e60\u5904\u7406\uff0c\u5c06AI\u7684\u4f18\u52bf\u53d1\u6325\u5230\u4e86\u6781\u81f4\uff0c\u6240\u4ee5\u5b83\u6bd4\u7b2c\u4e00\u7c7b\u7b97\u6cd5\u7684\u81ea\u52a8\u5316\u7a0b\u5ea6\u66f4\u9ad8\uff0c\u7cbe\u5ea6\u4e5f\u66f4\u597d\u3002<\/p>\n\n\n\n<p>\u603b\u4f53\u800c\u8a00\uff0c\u6df1\u5ea6\u5b66\u4e60\u7b97\u6cd5\u5728\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u7684\u7cbe\u5ea6\u4e0a\u5df2\u7ecf\u5168\u9762\u8d85\u8fc7\u4e86\u4f20\u7edf\u7b97\u6cd5\u3002<strong>\u5176\u4e3b\u8981\u4f18\u52bf\u5728\u4e8e\u53ef\u4ee5\u63a7\u5236\u3001\u8bad\u7ec3\u975e\u5e38\u5927\u89c4\u6a21\u7684\u53ef\u8c03\u53c2\u6570\uff0c\u800c\u57fa\u4e8e\u7edf\u8ba1\u7269\u7406\u7684\u4f20\u7edf\u7b97\u6cd5\u4e00\u822c\u53ea\u6709\u51e0\u5341\u6700\u591a\u6570\u767e\u4e2a\u53ef\u8c03\u53c2\u6570\u3002<\/strong>\u5982\u679c\u628a\u86cb\u767d\u8d28\u5206\u5b50\u5904\u7406\u6210\u4e00\u4e2a\u7edf\u8ba1\u7cfb\u7edf\uff0c\u540e\u8005\u8fd9\u79cd\u6709\u9650\u7684\u53ef\u8c03\u53c2\u6570\u7ed9\u5b83\u5bf9\u86cb\u767d\u8d28\u590d\u6742\u76f8\u4e92\u4f5c\u7528\u7684\u63cf\u8ff0\u5e26\u6765\u4e86\u4e00\u79cd\u5929\u7136\u7684\u5c40\u9650\u6027\u3002\u503c\u5f97\u5f3a\u8c03\u7684\u662f\uff0c\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u4e2d\u7684\u6df1\u5ea6\u5b66\u4e60\u662fAI\u5728\u7ed3\u6784\u9884\u6d4b\u9886\u57df\u7684\u5e94\u7528\uff0c\u6700\u591a\u7b97\u662f\u5bf9\u73b0\u6709AI\u6280\u672f\u7684\u5e94\u7528\u548c\u63a8\u5e7f\uff0c\u800c\u4e0d\u662f\u65b0\u7684AI\u7b97\u6cd5\u7684\u5f00\u53d1\u3002<\/p>\n\n\n\n<p><strong>\u300a\u73af\u7403\u79d1\u5b66\u300b\uff1a<\/strong><\/p>\n\n\n\n<p>\u90a3\u5728\u57fa\u4e8e\u6df1\u5ea6\u5b66\u4e60\u7684\u8fd9\u4e9b\u5de5\u4f5c\u4e2d\uff0c\u9664\u4e86AlphaFold\uff0c\u8fd8\u6709\u5176\u4ed6\u8868\u73b0\u51fa\u8272\u7684\u5de5\u5177\u5417\uff1f<\/p>\n\n\n\n<p><strong>\u5f20\u9633\uff1a<\/strong><\/p>\n\n\n\n<p>\u5176\u5b9e\uff0c<strong>Meta\u516c\u53f8\u5f00\u53d1\u7684ES<\/strong><strong>M\u548cESMFold<\/strong>\u4e5f\u8868\u73b0\u5f97\u975e\u5e38\u51fa\u8272\u3002\u76f8\u6bd4\u4e8eAlphaFold\uff0cESMFold\u66f4\u63a5\u8fd1ChatGPT\u3002\u5b83<strong>\u5c06\u86cb\u767d\u8d28\u7684\u6c28\u57fa\u9178\u5e8f\u5217\u89c6\u4e3a\u4e00\u79cd\u8bed\u8a00<\/strong>\uff0c\u7c7b\u4f3c\u4e8eChatGPT\u5904\u7406\u4eba\u7c7b\u8bed\u8a00\u6587\u672c\u7684\u65b9\u5f0f\uff0c\u4ee5\u6b64\u63ed\u793a\u86cb\u767d\u8d28\u7684\u7ed3\u6784\u3001\u6f14\u5316\u8fc7\u7a0b\u53ca\u5176\u7279\u6709\u7684\u201c\u8bed\u6cd5\u201d\u89c4\u5f8b\uff0c\u4ece\u800c\u5e2e\u52a9\u6211\u4eec\u98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