{"id":1739,"date":"2024-12-18T22:01:00","date_gmt":"2024-12-18T14:01:00","guid":{"rendered":"https:\/\/www.huanqiukexue.com\/?p=1739"},"modified":"2024-12-24T15:38:03","modified_gmt":"2024-12-24T07:38:03","slug":"%e5%9b%a0%e4%b8%ba%e6%84%9f%e6%9f%93%e6%96%b0%e5%86%a0%ef%bc%8c%e4%bb%96%e7%9a%84%e8%82%bf%e7%98%a4%e7%bc%a9%e5%b0%8f%e4%ba%86","status":"publish","type":"post","link":"https:\/\/www.huanqiukexue.com\/?p=1739","title":{"rendered":"\u56e0\u4e3a\u611f\u67d3\u65b0\u51a0\uff0c\u4ed6\u7684\u80bf\u7624\u7f29\u5c0f\u4e86"},"content":{"rendered":"
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\u5df4\u62c9\u7279\u7814\u7a76\u56e2\u961f\u7684\u6210\u5458\u6b63\u5728\u5904\u7406\u7ec4\u7ec7\u6837\u672c\uff08\u56fe\u7247\u6765\u6e90\uff1aNorthwestern Medicine\uff09<\/span><\/figcaption><\/figure>\n<\/div>\n\n\n
\u64b0\u6587 | \u51ac\u9e22
\u5ba1\u6821 | clefable

<\/strong>\n\n\n\n

\u90a3\u573a\u5e2d\u5377\u5168\u7403\u7684\u75ab\u60c5\u4ecd\u8ba9\u4eba\u5370\u8c61\u6df1\u523b\u3002\u8bb8\u591a\u60a3\u8005\uff0c\u5c24\u5176\u662f\u8001\u5e74\u60a3\u8005\uff0c\u56e0\u4e3a\u540c\u65f6\u60a3\u6709\u5176\u4ed6\u75be\u75c5\uff0c\u6bd4\u5982\u5fc3\u8840\u7ba1\u75be\u75c5\uff0c\u5bfc\u81f4\u4ed6\u4eec\u611f\u67d3\u65b0\u51a0\u4e4b\u540e\uff0c\u540c\u65f6\u51fa\u73b0\u5f88\u4e25\u91cd\u7684\u5e76\u53d1\u75c7<\/strong>\uff0c\u75c5\u60c5\u53d8\u5f97\u66f4\u52a0\u4e25\u91cd\u3002<\/p>\n\n\n\n

\u7136\u800c\uff0c\u6709\u4e00\u4e9b\u96f6\u661f\u7684\u60a3\u8005\uff0c\u5728\u60a3\u4e0a\u65b0\u51a0\u4e4b\u540e\uff0c\u81ea\u5df1\u672c\u8eab\u60a3\u6709\u7684\u4e0d\u6cbb\u4e4b\u75c7\u2014\u2014\u764c\u75c7\u2014\u2014\u5374\u56e0\u6b64\u51cf\u8f7b\u4e86<\/strong>\u3002<\/p>\n\n\n\n



\u65b0\u51a0\u75c5\u6bd2\u6cbb\u7597\u764c\u75c7\uff1f<\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/span><\/mark><\/strong><\/p>\n\n\n\n

2021\u5e74\u53d1\u8868\u7684\u4e00\u9879\u7814\u7a76\u4e2d\u63d0\u5230\uff0c\u4e00\u540d71\u5c81\u7684\u7537\u6027\u5728CT\u626b\u63cf\u4e2d\u88ab\u53d1\u73b0\u6709\u80be\u80bf\u7624\uff0c\u800c\u4e0d\u4e45\u4e4b\u540e\uff08\u5927\u6982\u662f2020\u5e7411\u6708\uff09\u4ed6\u53c8\u786e\u8bca\u4e86\u65b0\u51a0\u611f\u67d3\uff0c\u4f46\u6ca1\u6709\u63a5\u53d7\u65b0\u51a0\u76f8\u5173\u7684\u7279\u6b8a\u6cbb\u7597\u3002\u65b0\u51a0\u9694\u79bb\u671f\u7ed3\u675f\u540e\uff0c\u8fd9\u4f4d\u60a3\u8005\u63a5\u53d7\u4e86\u80be\u5207\u9664\u672f\uff0c\u4f46\u80bf\u7624\u5df2\u7ecf\u53d1\u751f\u4e86\u8f6c\u79fb\u3002\u800c\u57282021\u5e742\u6708\uff0c\u4e5f\u5c31\u662f\u4ed6\u786e\u8bca\u65b0\u51a0\u611f\u67d3\u7ea63\u4e2a\u6708\u540e\uff0cCT\u626b\u63cf\u663e\u793a\uff0c\u4ed6\u6240\u6709\u7684\u8f6c\u79fb\u6027\u80bf\u7624\u90fd\u5df2\u5927\u5e45\u6d88\u9000<\/strong>\u3002<\/p>\n\n\n\n

\u7c7b\u4f3c\u8fd9\u6837\u764c\u75c7\u56e0\u65b0\u51a0\u75c5\u6bd2\u800c\u7f13\u89e3\u7684\u6848\u4f8b\u5e76\u975e\u4e2a\u4f8b\u3002\u53bb\u5e744\u6708\u53d1\u8868\u5728\u300a\u8f6c\u5316\u533b\u5b66\u6742\u5fd7\u300b\uff08Journal of Translational Medicine<\/em>\uff09\u4e0a\u7684\u7814\u7a76\u8be6\u7ec6\u603b\u7ed3\u5206\u6790\u4e8616\u4f8b\u8fd9\u6837\u7684\u75c5\u4f8b\uff0c\u5176\u4e2d14\u4f8b\u60a3\u8005\u5728\u611f\u67d3\u65b0\u51a0\u75c5\u6bd2\u540e\uff0c\u672c\u8eab\u60a3\u6709\u7684\u6dcb\u5df4\u7624\u3001\u80be\u7ec6\u80de\u764c\u6216\u7ed3\u76f4\u80a0\u764c\u7b49\u764c\u75c7\u90fd\u53d1\u751f\u7f13\u89e3<\/strong>\uff1b\u53e6\u59162\u4f8b\u5219\u662f\u60a3\u8005\u5728\u63a5\u79cd\u65b0\u51a0\u75ab\u82d7\u540e\uff0c\u53d1\u751f\u4e86\u764c\u75c7\u7684\u7f13\u89e3\u3002<\/p>\n\n\n

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\u5206\u522b\u62cd\u6444\u4e8e2020\u5e748\u6708\uff0c2021\u5e742\u6708\u4e0e2021\u5e745\u6708\u7684CT\u56fe\u50cf\u663e\u793a\u80bf\u7624\u6b63\u5728\u7f29\u5c0f\uff08\u56fe\u7247\u6765\u6e90\uff1aBuchler et al, 2021\uff09<\/span><\/figcaption><\/figure>\n<\/div>\n\n\n

\u81f3\u4e8e\u4e3a\u4ec0\u4e48\u65b0\u51a0\u75c5\u6bd2\u53ef\u4ee5\u7f13\u89e3\u8fd9\u4e9b\u60a3\u8005\u7684\u764c\u75c7\uff0c\u5f53\u65f6\u7814\u7a76\u8005\u63d0\u51fa\u4e86\u4e00\u4e9b\u53ef\u80fd\u7684\u731c\u60f3\u548c\u5047\u8bbe\u3002\u5176\u4e2d\u4e00\u79cd\u53ef\u80fd\u662f\uff0c\u65b0\u51a0\u75c5\u6bd2\u6216\u8bb8\u662f\u4e00\u79cd\u6eb6\u7624\u75c5\u6bd2\uff08oncolytic virus\uff09\uff0c\u80fd\u591f\u653b\u51fb\u764c\u7ec6\u80de\u3002\u4e8b\u5b9e\u4e0a\uff0c\u8bb8\u591a\u80fd\u611f\u67d3\u4eba\u7684\u75c5\u6bd2\uff08\u6bd4\u5982\u5be8\u5361\u75c5\u6bd2\uff09\uff0c\u9664\u4e86\u80fd\u653b\u51fb\u4eba\u4f53\u7684\u6b63\u5e38\u7ec6\u80de\u548c\u7ec4\u7ec7\u4e4b\u5916\uff0c\u4e5f\u5177\u6709\u653b\u51fb\u4eba\u4f53\u5185\u764c\u7ec6\u80de\u7684\u80fd\u529b<\/strong>\u3002\u800c\u8fd9\u4fbf\u53ef\u80fd\u8ba9\u611f\u67d3\u4e86\u8fd9\u4e9b\u75c5\u6bd2\u7684\u764c\u75c7\u60a3\u8005\u201c\u56e0\u7978\u5f97\u798f\u201d\uff0c\u81ea\u5df1\u4f53\u5185\u7684\u764c\u75c7\u56e0\u4e3a\u8fd9\u4e9b\u75c5\u6bd2\u800c\u7f13\u89e3\u3002\u8fd9\u4e00\u7c7b\u80fd\u591f\u653b\u51fb\u764c\u7ec6\u80de\u7684\u75c5\u6bd2\u5c31\u53eb\u505a\u6eb6\u7624\u75c5\u6bd2\u3002<\/p>\n\n\n\n

\u76ee\u524d\u4e5f\u6709\u5f88\u591a\u7814\u7a76\u8bd5\u56fe\u5bf9\u7279\u5b9a\u6eb6\u7624\u75c5\u6bd2\u8fdb\u884c\u6539\u9020\uff0c\u4ece\u800c\u8fbe\u5230\u6cbb\u7597\u764c\u75c7\u7684\u76ee\u7684\u3002\u4e00\u4e9b\u76f8\u5173\u836f\u7269\u5df2\u7ecf\u6279\u51c6\u4e0a\u5e02\uff0c\u53e6\u5916\u8fd8\u6709\u5f88\u591a\u5904\u4e8e\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u3002\u5927\u5bb6\u6216\u8bb8\u5bf9\u4e0a\u4e2a\u6708\u7684\u4e00\u6761\u65b0\u95fb\u8fd8\u6709\u5370\u8c61\uff1a\u79d1\u5b66\u5bb6\u8d1d\u4e9a\u5854\u00b7\u54c8\u62c9\u897f\uff08Beata Halassy\uff09\u5728\u60a3\u665a\u671f\u4e73\u817a\u764c\u540e\uff0c\u901a\u8fc7\u81ea\u5df1\u5728\u5b9e\u9a8c\u5ba4\u4e2d\u57f9\u517b\u7684\u4e24\u79cd\u6eb6\u7624\u75c5\u6bd2\u6cbb\u7597\u81ea\u5df1\uff0c\u6210\u529f\u6e05\u9664\u4e86\u4f53\u5185\u7684\u80bf\u7624<\/strong>\uff0c4\u5e74\u5185\u6ca1\u6709\u590d\u53d1\u3002\u8fd9\u4e00\u5192\u9669\u4e4b\u4e3e\u867d\u7136\u6551\u4e86\u5979\u81ea\u5df1\uff0c\u4f46\u4e0d\u503c\u5f97\u63a8\u5d07\uff0c\u56e0\u4e3a\u4e0d\u786e\u5b9a\u6027\u592a\u591a\uff0c\u666e\u901a\u60a3\u8005\u8fd8\u662f\u5e94\u8be5\u4f7f\u7528\u5df2\u5728\u4e34\u5e8a\u9a8c\u8bc1\u7684\u7597\u6cd5\uff0c\u4e0d\u8981\u6548\u4eff\u5979\u3002<\/p>\n\n\n\n

\u4f46\u6700\u8fd1\u53d1\u8868\u5728The Journal of Clinical Investigation<\/em>\u4e0a\u7684\u4e00\u9879\u65b0\u7814\u7a76\u5219\u8868\u660e\uff0c\u611f\u67d3\u65b0\u51a0\u75c5\u6bd2\u80fd\u7f13\u89e3\u764c\u75c7\uff0c\u6216\u8bb8\u662f\u51fa\u4e8e\u4e00\u79cd\u66f4\u201c\u620f\u5267\u6027\u201d\u7684\u539f\u56e0\u3002<\/p>\n\n\n\n



\u7b56\u53cd\u514d\u75ab\u7ec6\u80de\u7684\u80bf\u7624<\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/span><\/mark><\/strong><\/p>\n\n\n\n

\u4f17\u6240\u5468\u77e5\uff0c\u80bf\u7624\u6765\u6e90\u4e8e\u4f53\u5185\u6b63\u5e38\u7ec6\u80de\u7684\u53d8\u5f02\u3002\u80bf\u7624\u80fd\u591f\u5728\u4eba\u4f53\u5185\u201c\u6a2a\u884c\u9738\u9053\u201d\uff0c\u79bb\u4e0d\u5f00\u5b83\u4eec\u9003\u907f\u514d\u75ab\u7cfb\u7edf\u68c0\u6d4b\u548c\u653b\u51fb\u7684\u80fd\u529b\u3002\u5b83\u4eec\u9003\u907f\u514d\u75ab\u7cfb\u7edf\u653b\u51fb\u7684\u65b9\u6cd5\u6709\u5f88\u591a\uff0c\u5176\u4e2d\u4e4b\u4e00\u4fbf\u662f\u201c\u7b56\u53cd\u201d\u514d\u75ab\u7ec6\u80de\uff0c\u8ba9\u5176\u5e2e\u52a9\u81ea\u5df1\u8eb2\u5f00\u514d\u75ab\u7cfb\u7edf\u7684\u76d1\u6d4b<\/strong>\u3002<\/p>\n\n\n\n

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\u540c\u65f6\uff0c\u80bf\u7624\u4f1a\u5206\u6ccc\u4e00\u4e9b\u7269\u8d28\u6539\u53d8\u81ea\u5df1\u7684\u5fae\u73af\u5883\uff0c\u8fd9\u4e9b\u5355\u6838\u7ec6\u80de\u88ab\u62db\u52df\u5230\u80bf\u7624\u533a\u57df\u540e\uff0c\u4f1a\u53d1\u751f\u8868\u89c2\u9057\u4f20\u7684\u53d8\u5316\uff0c\u8f6c\u5316\u4e3a\u80bf\u7624\u76f8\u5173\u5de8\u566c\u7ec6\u80de\uff08tumor-associated macrophages, TAMs\uff09<\/strong>\u3002TAMs\u76f8\u5173\u7684\u514d\u75ab\u80fd\u529b\u53d7\u5230\u6291\u5236\uff0c\u4f1a\u5e2e\u52a9\u80bf\u7624\u8eb2\u907fT\u7ec6\u80de\u548c\u81ea\u7136\u6740\u4f24\u7ec6\u80de\uff08natural killer cell\uff09\u7b49\u7684\u653b\u51fb\u3002\u540c\u65f6\uff0cTAMs\u8fd8\u4f1a\u91ca\u653e\u4e00\u4e9b\u751f\u957f\u56e0\u5b50\u7b49\u5e2e\u52a9\u764c\u7ec6\u80de\u7684\u751f\u957f\u548c\u6269\u6563\u3002<\/p>\n\n\n\n

\u867d\u7136\u4eba\u4f53\u5185\u4f1a\u5b58\u5728\u4e00\u4e9b\u6ca1\u6709CCR2\u53d7\u4f53\u7684\u975e\u7ecf\u5178\u5355\u6838\u7ec6\u80de\uff08nonclassical monocytes, NCMs\uff09\uff0c\u4e0d\u4f1a\u88ab\u80bf\u7624\u901a\u8fc7CCL2\u62db\u52df\uff0c\u4ecd\u7136\u5177\u6709\u6297\u764c\u7684\u80fd\u529b\uff0c\u4f46\u4e5f\u6b63\u56e0\u4e3a\u7f3a\u4e4fCCR2\uff0c\u5b83\u4eec\u901a\u5e38\u6ca1\u529e\u6cd5\u6df1\u5165\u80bf\u7624\u5185\u90e8\u53d1\u6325\u4f5c\u7528<\/strong>\u3002<\/p>\n\n\n

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CCL2-CCR2\u5728\u80bf\u7624\u53d1\u751f\u4e2d\u7684\u4f5c\u7528\uff08\u56fe\u7247\u6765\u6e90\uff1aXu et al, 2021\uff09<\/span><\/figcaption><\/figure>\n<\/div>\n\n\n



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\u800c\u7814\u7a76\u8005\u53d1\u73b0\uff0c\u5f53\u60a3\u8005\u6216\u5c0f\u9f20\u611f\u67d3\u65b0\u51a0\u75c5\u6bd2\u540e<\/strong>\uff0c\u4f1a\u5f15\u53d1\u708e\u75c7\uff0c\u540c\u65f6\u5bfc\u81f4\u4f53\u5185\u4ea7\u751f\u4e00\u79cd\u5728\u81ea\u7136\u60c5\u51b5\u4e0b\u5f88\u5c11\u5b58\u5728\u7684\u975e\u7ecf\u5178\u5355\u6838\u7ec6\u80de\u2014\u2014\u201c\u53ef\u8bf1\u5bfc\u975e\u7ecf\u5178\u5355\u6838\u7ec6\u80de\u201d\uff08I-NCM\uff09<\/strong>\u2014\u2014\u6765\u5bf9\u6297\u65b0\u51a0\u75c5\u6bd2\u3002\u8fd9\u4e9bI-NCM\u7684\u7279\u6b8a\u4e4b\u5904\u5728\u4e8e\uff0c\u5b83\u4eec\u5177\u6709\u653b\u51fb\u80bf\u7624\u7684\u80fd\u529b\uff0c\u8fd8\u80fd\u8fdb\u5165\u80bf\u7624\u5185\u90e8\u3002<\/p>\n\n\n\n

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\u53c2\u8003\u94fe\u63a5\uff1a
https:\/\/www.jci.org\/articles\/view\/179527
https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cpr.13115
https:\/\/translational-medicine.biomedcentral.com\/articles\/10.1186\/s12967-023-04110-w
https:\/\/www.mdpi.com\/1718-7729\/28\/5\/294
https:\/\/news.feinberg.northwestern.edu\/2024\/11\/18\/new-research-sheds-light-on-a-surprising-connection-between-covid-19-and-cancer-regression\/
https:\/\/theconversation.com\/covid-caused-cancer-tumours-to-shrink-in-mice-new-study-243973
https:\/\/mp.weixin.qq.com\/s\/T3TPBggw4WueChO_TYlpFQ
https:\/\/jitc.bmj.com\/content\/10\/3\/e004371
<\/strong>\n","protected":false},"excerpt":{"rendered":"

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