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\u56fe\u7247\u6765\u6e90\uff1aColumbia University Irving Medical Center<\/a><\/span><\/figcaption><\/figure>\n<\/div>\n\n\n
\u7b97\u4e0d\u7b97\u662f\u4e00\u79cd\u56e0\u7978\u5f97\u798f\u5462\u3002<\/section>\n\n\n\n
\u64b0\u6587 | \u51ac\u9e22
\u5ba1\u6821 | clefable

<\/strong>\n\n\n\n

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\u535a\u53e4\u8bfa\u7ef4\u5947\u548c\u540c\u4e8b\u5bf9\u4e24\u59d0\u59b9\u53ca\u5979\u4eec\u5065\u5eb7\u7684\u6bcd\u4eb2\u8fdb\u884c\u4e86\u5168\u5916\u663e\u5b50\u6d4b\u5e8f\u3002\u7ed3\u679c\u53d1\u73b0\uff0c\u5979\u4eec<\/strong>ISG15<\/em><\/strong>\u57fa\u56e0\u53d1\u751f\u4e86\u7a81\u53d8<\/strong>\uff08\u6bcd\u4eb2\u6709\u4e00\u6761\u67d3\u8272\u4f53\u53d1\u751f\u7a81\u53d8\uff0c\u800c\u5973\u513f\u662f\u9690\u6027\u7eaf\u5408\u5b50\uff09\uff0c\u4ece\u800c\u4e0d\u80fd\u6b63\u5e38\u53d1\u6325\u4f5c\u7528\u3002\u800c\u8fd9\u8ba9\u7814\u7a76\u8005\u8054\u60f3\u5230\u4e86\u6b64\u524d\u5728\u571f\u8033\u5176\u548c\u4f0a\u6717\u9047\u5230\u7684\u4e09\u540d\u513f\u7ae5\u60a3\u8005\uff1a\u4ed6\u4eec\u90fd\u662f\u6765\u81ea\u8fd1\u4eb2\u7ed3\u5a5a\u7684\u5bb6\u5ead\uff0c\u8868\u73b0\u51fa\u5bf9\u5361\u4ecb\u82d7\uff08BCG\uff09\u7b49\u4e2d\u51cf\u6bd2\u5206\u679d\u6746\u83cc\u7684\u9ad8\u5ea6\u6613\u611f\uff0c\u8fd9\u662f\u4e00\u79cd\u540d\u4e3a\u9057\u4f20\u6027\u5206\u679d\u6746\u83cc\u6613\u611f\u75c5\uff08Mendelian susceptibility to mycobacterial disease, MSMD\uff09\u7684\u7f55\u89c1\u75c5\u7684\u5178\u578b\u8868\u73b0\u3002\u4e0d\u8fc7\uff0c\u8fd93\u540d\u513f\u7ae5\u4e0d\u4f1a\u51fa\u73b0\u4e25\u91cd\u7684\u75c5\u6bd2\u611f\u67d3<\/strong>\u3002<\/p>\n\n\n\n

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\u51e0\u540d\u60a3\u8005\u7684\u5bb6\u5ead\u9057\u4f20\u5206\u6790\u56fe\uff08\u6765\u6e90\uff1aZhang et al, 2014<\/a>\uff09<\/span><\/figcaption><\/figure>\n<\/div>\n\n\n

\u571f\u8033\u5176\u548c\u4f0a\u6717\u7684\u75c5\u4f8b\u4e8e2012\u5e74\u53d1\u8868\u5728\u300a\u79d1\u5b66\u300b\uff08Science<\/em>\uff09\u4e0a\uff0c\u800c\u4e2d\u56fd\u4e09\u59d0\u59b9\u7684\u75c5\u4f8b\u4e8e2014\u5e74\u9996\u6b21\u5728\u300a\u81ea\u7136\u300b\uff08Nature<\/em>\uff09\u4e0a\u88ab\u63d0\u5230\u3002\u8ba9\u7814\u7a76\u8005\u611f\u5230\u4e0d\u53ef\u601d\u8bae\u7684\u662f\uff0c\u8fd9\u4e9bISG15<\/em>\u57fa\u56e0\u7f3a\u9677\u60a3\u8005\uff0c\u5bf9\u75c5\u6bd2\u4f3c\u4e4e\u5177\u6709\u8d85\u4e4e\u5bfb\u5e38\u7684\u62b5\u6297\u529b<\/strong>\u3002\u4ed6\u4eec\u7684\u514d\u75ab\u7cfb\u7edf\u4e2d\u5b58\u5728\u591a\u79cd\u5e38\u89c1\u75c5\u6bd2\uff08\u6bd4\u5982\u6d41\u611f\u3001\u9ebb\u75b9\u75c5\u6bd2\u3001\u816e\u817a\u708e\u75c5\u6bd2\u3001\u6c34\u75d8\u75c5\u6bd2\u7b49\uff09\u7684\u6297\u4f53\uff0c\u8bf4\u660e\u4ed6\u4eec\u66fe\u7ecf\u611f\u67d3\u8fc7\u8fd9\u4e9b\u75c5\u6bd2\uff0c\u4f46\u4ece\u672a\u51fa\u73b0\u8fc7\u76f8\u5173\u7684\u4e25\u91cd\u75c5\u75c7<\/strong>\u3002<\/p>\n\n\n\n



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\u8981\u89e3\u91ca\u8fd9\u4e00\u73b0\u8c61\uff0c\u5c31\u5fc5\u987b\u7406\u89e3ISG15\u5728\u4eba\u4f53\u5185\u7684\u89d2\u8272\u3002ISG15\u6709\u4e24\u91cd\u8eab\u4efd\uff1a\u5728\u7ec6\u80de\u5916\uff0c\u5b83\u662f\u4fc3\u8fdb\u6dcb\u5df4\u7ec6\u80de\u4ea7\u751f\u03b3\u5e72\u6270\u7d20\uff08IFN-\u03b3\uff09\u7684\u4fe1\u53f7\u5206\u5b50<\/strong>\uff0c\u5e2e\u52a9\u5bf9\u4ed8\u5206\u679d\u6746\u83cc\uff1b\u800c\u5728\u7ec6\u80de\u5185\uff0c\u5b83\u771f\u6b63\u7684\u4f5c\u7528\u662f\u7ef4\u6301USP18\u7684\u7a33\u5b9a\u3002USP18\u662fI\u578b\u5e72\u6270\u7d20\u901a\u8def\u4e2d\u7684\u201c\u5239\u8f66\u201d\uff0c\u53ef\u4ee5\u9632\u6b62IFN-\u03b1\u548cIFN-\u03b2\u7b49\uff08\u4e3b\u8981\u4f5c\u7528\u662f\u6fc0\u6d3b\u6297\u75c5\u6bd2\u57fa\u56e0\uff0c\u963b\u6b62\u75c5\u6bd2\u589e\u6b96\u7b49\uff09\u8fc7\u5ea6\u53d1\u6325\u4f5c\u7528\u3002\u5982\u679c\u6ca1\u6709ISG15\uff0cUSP18\u4f1a\u8fc5\u901f\u964d\u89e3\uff0c\u5bfc\u81f4I\u578b\u5e72\u6270\u7d20\u4fe1\u53f7\u6301\u7eed\u653e\u5927\u3002\u8fd9\u6837\u4e00\u6765\uff0c\u60a3\u8005\u4f53\u5185\u4f1a\u957f\u671f\u7ef4\u6301\u4e00\u79cd\u8f7b\u5ea6\u4f46\u5e7f\u8c31\u7684\u6297\u75c5\u6bd2\u201c\u5e95\u566a\u201d<\/strong>\uff0c\u65e2\u8ba9\u75c5\u6bd2\u66f4\u96be\u4ee5\u590d\u5236\uff0c\u53c8\u907f\u514d\u4e86\u5168\u529b\u62c9\u54cd\u5e72\u6270\u7d20\u8b66\u62a5\u5e26\u6765\u7684\u5371\u5bb3\u3002\u8fd9\u4e5f\u662f\u4e3a\u4ec0\u4e48\u8fd9\u4e9b\u60a3\u8005\u5bf9\u75c5\u6bd2\u8868\u73b0\u51fa\u5f3a\u5927\u62b5\u6297\u529b\uff0c\u5374\u5bf9\u5206\u679d\u6746\u83cc\u7684\u9632\u5fa1\u5b58\u5728\u7f3a\u9677\u3002<\/p>\n\n\n\n

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\u53c2\u8003\u94fe\u63a5\uff1a
https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.adx5758
https:\/\/www.cell.com\/trends\/immunology\/abstract\/S1471-4906(16)30181-8
https:\/\/www.science.org\/doi\/10.1126\/science.1224026
https:\/\/www.nature.com\/articles\/nature13801
https:\/\/www.nature.com\/articles\/ncomms11496
https:\/\/www.cuimc.columbia.edu\/news\/one-universal-antiviral-rule-them-all
<\/strong>\n","protected":false},"excerpt":{"rendered":"

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