{"id":3403,"date":"2025-11-27T22:00:00","date_gmt":"2025-11-27T14:00:00","guid":{"rendered":"https:\/\/www.huanqiukexue.com\/?p=3403"},"modified":"2025-11-28T17:50:47","modified_gmt":"2025-11-28T09:50:47","slug":"%e6%89%8b%e6%8c%87%e3%80%81%e8%84%9a%e8%b6%be%e6%8e%a5%e8%bf%9e%e8%82%bf%e8%83%80%e5%90%8e%ef%bc%8c%e4%bb%96%e6%89%8d%e5%8f%91%e7%8e%b0%e7%99%8c%e7%97%87%e5%b7%b2%e7%bb%8f%e6%89%a9%e6%95%a3%e5%88%b0","status":"publish","type":"post","link":"https:\/\/www.huanqiukexue.com\/?p=3403","title":{"rendered":"\u624b\u6307\u3001\u811a\u8dbe\u63a5\u8fde\u80bf\u80c0\u540e\uff0c\u4ed6\u624d\u53d1\u73b0\u764c\u75c7\u5df2\u7ecf\u6269\u6563\u5230\u4e86\u5168\u8eab"},"content":{"rendered":"\n<figure class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"337\" src=\"https:\/\/www.huanqiukexue.com\/wp-content\/uploads\/2025\/11\/wechat_image_5-10.jpg\" alt=\"\" class=\"wp-image-3401\" srcset=\"https:\/\/www.huanqiukexue.com\/wp-content\/uploads\/2025\/11\/wechat_image_5-10.jpg 600w, https:\/\/www.huanqiukexue.com\/wp-content\/uploads\/2025\/11\/wechat_image_5-10-300x169.jpg 300w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><\/figure>\n\n\n\n<p><span style=\"color: rgb(153, 153, 153); font-size: 16px; letter-spacing: 1px;\">\u56fe\u7247\u6765\u6e90\u4e8e<a target=\"_blank\" href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMicm2501158\" rel=\"noreferrer noopener\"><em>NEJM<\/em>\u8bba\u6587<\/a><\/span><\/p>\n\n\n\n<p><span style=\"color: rgb(153, 153, 153); font-size: 16px; letter-spacing: 1px;\">\u64b0\u6587\uff5cclefable<\/span><\/p>\n\n\n\n<p><span style=\"color: rgb(153, 153, 153); font-size: 16px; letter-spacing: 1px;\">\u5ba1\u6821\uff5c\u51ac\u9e22<\/span><\/p>\n\n\n\n<p>7\u670816\u65e5\uff0c<a target=\"_blank\" href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMicm2501158\" rel=\"noreferrer noopener\">\u300a\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\u300b<\/a>\uff08<em>NEJM<\/em>\uff09\u53d1\u8868\u4e86\u4e00\u4efd\u8fd9\u6837\u7684\u75c5\u4f8b\u62a5\u544a\uff1a\u4e00\u540d55\u5c81\u7684\u60a3\u8005<strong>\u57286\u5468\u5185\u53f3\u624b\u7684\u4e2d\u6307\u548c\u5927\u811a\u8dbe\u63a5\u8fde\u51fa\u73b0\u75bc\u75db\u548c\u80bf\u80c0<\/strong>\uff0c\u6307\u7532\u9644\u8fd1\u8fd8\u957f\u51fa\u4e86\u6e83\u75a1\u3002<\/p>\n\n\n\n<p>\u80bf\u80c0\u90e8\u4f4d\u7684\u89e6\u611f\u5341\u5206\u575a\u786c\uff0c\u4e14\u6709\u538b\u75db\u611f\u3002\u867d\u7136\u5f88\u50cf\u662f\u75db\u98ce\u548c\u9aa8\u9ad3\u708e\uff0c\u4f46\u60a3\u8005\u7684X\u5c04\u7ebf\u626b\u63cf\u56fe\u7ed9\u51fa\u4e86\u7cdf\u7cd5\u7684\u7ed3\u679c\u2014\u2014<strong>\u4ed6\u7684\u53f3\u624b\u4e2d\u6307\u548c\u5927\u811a\u8dbe\u7684\u9aa8\u9abc\u51e0\u4e4e\u4e0d\u89c1\u4e86<\/strong>\u3002\u8fd9\u662f\u4e00\u79cd\u4e25\u91cd\u7684<strong>\u6eb6\u9aa8\u6027\u75c5\u53d8<\/strong>\uff0c\u4e00\u822c\u7531\u80bf\u7624\u5f15\u8d77\u3002\u5982\u679c\u68c0\u6d4b\u7684\u7ed3\u679c\u662f\uff0c\u9aa8\u9abc\u4e2d\u51fa\u73b0\u4e86\u7834\u574f\u6027\u7684\u5b54\u6d1e\u548c\u5927\u8303\u56f4\u7684\u9634\u5f71\u533a\u57df\uff0c\u4e0d\u8981\u610f\u5916\uff0c\u8fd9\u4e5f\u662f\u6eb6\u9aa8\u6027\u75c5\u53d8\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"337\" src=\"https:\/\/www.huanqiukexue.com\/wp-content\/uploads\/2025\/11\/wechat_image_7-10.jpg\" alt=\"\" class=\"wp-image-3402\" srcset=\"https:\/\/www.huanqiukexue.com\/wp-content\/uploads\/2025\/11\/wechat_image_7-10.jpg 600w, https:\/\/www.huanqiukexue.com\/wp-content\/uploads\/2025\/11\/wechat_image_7-10-300x169.jpg 300w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><\/figure>\n\n\n\n<p><span style=\"color: rgb(153, 153, 153); font-size: 16px; letter-spacing: 1px;\">\u56fe\u7247\u6765\u6e90\u4e8e<a target=\"_blank\" href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMicm2501158\" rel=\"noreferrer noopener\"><em>NEJM<\/em>\u8bba\u6587<\/a><\/span><\/p>\n\n\n\n<p>\u5728\u4eba\u4f53\u5185\uff0c\u5f88\u591a\u6076\u6027\u764c\u7ec6\u80de\u4f1a\u8ba9\u9aa8\u9abc\u5468\u56f4\u7684\u7834\u9aa8\u7ec6\u80de\u8fc7\u5ea6\u6d3b\u5316\uff0c\u5bfc\u81f4\u9aa8\u5438\u6536\u7684\u901f\u5ea6\u8fdc\u5927\u4e8e\u5f62\u6210\u901f\u5ea6\uff0c\u6e10\u6e10\u5730\u539f\u672c\u575a\u786c\u7684\u9aa8\u9abc\u5c31\u4f1a\u53d8\u8584\uff0c\u751a\u81f3\u6d88\u5931\u3002\u8fd1\u671f\uff0c\u4e00\u9879\u53d1\u8868\u4e8e<a target=\"_blank\" href=\"https:\/\/www.nature.com\/articles\/s41593-025-02064-4\" rel=\"noreferrer noopener\">\u300a\u81ea\u7136\u00b7\u795e\u7ecf\u79d1\u5b66\u300b<\/a>\uff08<em>Nature Neuroscience<\/em>\uff09\u7684\u7814\u7a76\u53d1\u73b0\uff0c\u5927\u8111\u4e2d\u7684\u4e00\u79cd\u6076\u6027\u80bf\u7624\u2014\u2014<strong>\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u5c31\u4f1a\u201c\u6d88\u89e3\u201d\u5c0f\u9f20\u7684\u5934\u9aa8<\/strong>\uff0c\u8ba9\u5b83\u4eec\u575a\u56fa\u7684\u8111\u58f3\u53d8\u5f97\u50cf\u867e\u58f3\u4e00\u6837\u8584\u3002\u800c\u5bf9\u4e8e\u8fd9\u7c7b\u80bf\u7624\u60a3\u8005\u7684\u89c2\u5bdf\u663e\u793a\uff0c<strong>\u4ed6\u4eec\u5934\u9aa8\u7684\u539a\u5ea6\u4e5f\u4f1a\u5e73\u5747\u51cf\u5c1120%<\/strong>\u3002\u53ea\u662f\u7b80\u5355\u60f3\u8c61\u4e0b\u8111\u58f3\u53d8\u867e\u58f3\uff0c\u5c31\u4f1a\u611f\u89c9\u6076\u6027\u764c\u75c7\u771f\u662f\u53ef\u6015\u3002<\/p>\n\n\n\n<p class=\"has-text-align-center has-medium-font-size\"><strong><mark style=\"background-color:rgba(0, 0, 0, 0);\"><span style=\"font-size: 24px; text-decoration: overline; caret-color: rgb(8,124,186); color: rgb(8,124,186);\"><strong><br><br>\u4e0d\u5e78\u7684\u9884\u5146<\/strong><\/span><\/mark><\/strong><\/p>\n\n\n\n<p>\u800c<em>NEJ<\/em><em>M<\/em>\u8bba\u6587\u4e2d\u7684\u60a3\u8005\u6709\u6b64\u906d\u9047\uff0c\u4e3b\u8981\u662f\u51fa\u73b0\u4e86\u80bf\u7624\u8f6c\u79fb\u3002\u6b64\u524d\uff0c\u4ed6\u66fe\u786e\u8bca\u4e86\u8f6c\u79fb\u6027\u9cde\u72b6\u7ec6\u80de\u80ba\u764c\uff08metastatic squamous-cell lung cancer\uff09\u3002\u9cde\u72b6\u7ec6\u80de\u662f\u80ba\u90e8\u6c14\u7ba1\u5185\u76ae\u4e0a\u7684\u7ec6\u80de\uff0c\u5b83\u4eec\u5728\u53d7\u5230\u957f\u671f\u523a\u6fc0\uff0c\u6bd4\u5982\u5438\u70df\u540e\uff0c\u5c31\u4f1a\u53d1\u751f\u764c\u53d8\u3002\u800c\u201c\u8f6c\u79fb\u6027\u201d\u6307\u7684\u662f\u80bf\u7624\u4ece\u521d\u59cb\u90e8\u4f4d\u6269\u6563\u5230\u4e86\u65b0\u7684\u5730\u65b9\uff0c\u8fdb\u5165\u4e86\u53d1\u5c55\u665a\u671f\u3002\u76ee\u524d\u8fd9\u7c7b\u764c\u75c7\u6781\u96be\u6cbb\u7597\uff0c\u4e00\u76f4\u662f\u79d1\u5b66\u5bb6\u957f\u671f\u653b\u575a\u7684\u65b9\u5411\u3002<\/p>\n\n\n\n<p>\u867d\u7136\u80ba\u764c\u5341\u5206\u5bb9\u6613\u8f6c\u79fb\u5230\u9aa8\u9abc\uff0c\u4f46\u8f6c\u79fb\u5230\u624b\u6307\u548c\u811a\u8dbe\u7684\u60c5\u51b5\u76f8\u5bf9\u5c11\u89c1\uff0c<strong>\u4ec5\u5360\u9aa8\u8f6c\u79fb\u76840.1%<\/strong>\u3002\u76f8\u6bd4\u4e8e\u9760\u8fd1\u5fc3\u810f\u7684\u9aa8\u9abc\uff0c\u6bd4\u5982\u810a\u67f1\u3001\u808b\u9aa8\u548c\u9aa8\u76c6\uff0c\u80a2\u7aef\u7684\u4f9b\u8840\u548c\u9aa8\u9ad3\u542b\u91cf\u660e\u663e\u66f4\u5c11\uff0c\u5e76\u4e0d\u5229\u4e8e\u764c\u75c7\u751f\u5b58\uff0c\u56e0\u6b64\u764c\u75c7\u6269\u6563\u5230\u80a2\u7aef\u7684\u6848\u4f8b\u5f88\u5c11\u3002<\/p>\n\n\n\n<p>\u4f46\u8fd9\u4e5f\u610f\u5473\u7740\uff0c\u8fd9\u79cd\u5411\u8eab\u4f53\u672b\u7aef\u7684\u8f6c\u79fb\u610f\u5473\u7740\uff0c\u764c\u7ec6\u80de\u6b63\u5728\u5411\u5168\u8eab\u6269\u6563\uff0c\u53ef\u80fd\u4f1a\u6709\u4e00\u4e2a\u60b2\u60e8\u7684\u7ed3\u5c40\uff1a<strong>\u60a3\u8005\u7684\u5b58\u6d3b\u65f6\u95f4\u6216\u5c06\u4e0d\u8db36\u4e2a\u6708<\/strong>\u3002\u8fd9\u4e00\u65f6\u671f\uff0c\u533b\u751f\u80fd\u91c7\u53d6\u7684\u6cbb\u7597\u901a\u5e38\u662f\u653e\u5c04\u6027\u59d1\u606f\u6cbb\u7597\uff0c\u4e3b\u8981\u4ee5\u7f13\u89e3\u60a3\u8005\u7684\u9aa8\u75db\u548c\u6291\u5236\u80bf\u7624\u7684\u53d1\u5c55\u4e3a\u4e3b\u3002\u7136\u800c\u4e0d\u5e78\u7684\u662f\uff0c\u968f\u7740\u4e00\u79cd\u9aa8\u9abc\u7834\u574f\u5bc6\u5207\u76f8\u5173\u7684\u5e76\u53d1\u75c7\u2014\u2014\u9ad8\u9499\u8840\u75c7\u7684\u51fa\u73b0\uff0c\u8fd9\u4f4d\u60a3\u8005\u5728\u77ed\u77ed3\u5468\u540e\u5c31\u5931\u53bb\u4e86\u751f\u547d\u3002<\/p>\n\n\n\n<p>\u5f53\u80bf\u7624\u8fc5\u901f\u53d1\u5c55\u65f6\uff0c\u5176\u5bf9\u9aa8\u9abc\u7684\u7834\u574f\u52a0\u91cd\uff0c\u8fc7\u591a\u7684\u9499\u4e5f\u4f1a\u88ab\u91ca\u653e\u5230\u8840\u6db2\u4e2d\uff0c\u7ed9\u60a3\u8005\u9020\u6210\u5168\u8eab\u6027\u7684\u5f71\u54cd\uff0c\u5305\u62ec\u5267\u70c8\u9aa8\u75db\u3001\u80be\u529f\u80fd\u7d0a\u4e71\u3001\u610f\u8bc6\u6df7\u4e71\u3001\u55dc\u7761\u4ee5\u53ca\u5fc3\u810f\u7535\u6d3b\u52a8\u5f02\u5e38\u7b49\u2014\u2014\u5982\u679c\u80bf\u7624\u65e0\u6cd5\u904f\u5236\uff0c\u8fd9\u53ef\u80fd\u662f\u5f88\u591a\u539f\u53d1\u6027\u548c\u8f6c\u79fb\u6027\u9aa8\u80bf\u7624\u60a3\u8005\u5728\u75be\u75c5\u665a\u671f\u7684\u906d\u9047\u3002<\/p>\n\n\n\n<p>\u4f46\u60c5\u51b5\u53ef\u80fd\u5e76\u975e\u603b\u662f\u5982\u6b64\u7cdf\u7cd5\u30022008\u5e74\uff0c\u4e00\u9879\u53d1\u8868\u4e8e<a target=\"_blank\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC2728313\/\" rel=\"noreferrer noopener\">\u300a\u82f1\u56fd\u7687\u5bb6\u5916\u79d1\u533b\u5b66\u9662\u5e74\u9274\u300b<\/a>\uff08<em>Annals of the Royal College of Surgeons of England<\/em>\uff09\u7684\u7814\u7a76\u63cf\u8ff0\u4e86\u8fd9\u6837\u4e00\u4f4d82\u5c81\u7684\u60a3\u8005\uff0c\u4ed6\u5728\u5c31\u8bca3\u5468\u524d<strong>\u51fa\u73b0\u53f3\u624b\u65e0\u540d\u6307\u80bf\u80c0\u3001\u89e6\u75db\u4e14\u80bf\u5757\u9010\u6e10\u589e\u5927<\/strong>\u7684\u60c5\u51b5\uff0c\u4f46\u6ca1\u6709\u5176\u4ed6\u751f\u7406\u75c7\u72b6\u3002\u533b\u751f\u901a\u8fc7X\u5149\u7247\u53d1\u73b0\u4ed6\u7684\u624b\u6307\u4e5f\u51fa\u73b0\u4e86\u7834\u574f\u6027\u7684\u6eb6\u9aa8\u6027\u75c5\u53d8\u3002<strong>\u901a\u8fc7\u7b5b\u67e5\uff0c\u4ed6\u4eec\u53d1\u73b0\u8be5\u60a3\u8005\u7684\u80c3\u539a\u58c1\u6709\u4e00\u4e2a\u8f83\u5927\u80bf\u5757\u2014\u2014\u6b64\u524d\u5e76\u6ca1\u6709\u88ab\u53d1\u73b0<\/strong>\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"386\" src=\"https:\/\/www.huanqiukexue.com\/wp-content\/uploads\/2025\/11\/wechat_image_1-9.jpg\" alt=\"\" class=\"wp-image-3399\" srcset=\"https:\/\/www.huanqiukexue.com\/wp-content\/uploads\/2025\/11\/wechat_image_1-9.jpg 600w, https:\/\/www.huanqiukexue.com\/wp-content\/uploads\/2025\/11\/wechat_image_1-9-300x193.jpg 300w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><\/figure>\n\n\n\n<p><span style=\"color: rgb(153, 153, 153); font-size: 16px; letter-spacing: 1px;\">\u56fe\u7247\u6765\u6e90\u4e8e\u53d1\u8868\u4e8e\u300a\u82f1\u56fd\u7687\u5bb6\u5916\u79d1\u533b\u5b66\u9662\u5e74\u9274\u300b\u7684\u8bba\u6587<\/span><\/p>\n\n\n\n<p>\u8fd9\u4e2a\u6848\u4f8b\u4f53\u73b0\u51fa\uff0c<strong>\u80a2\u7aef\u8f6c\u79fb\u7624\u53ef\u80fd\u662f\u4e00\u4e9b\u6f5c\u4f0f\u7684\u80bf\u7624\u7684\u9996\u4e2a\u75c7\u72b6<\/strong>\u3002\u8fd9\u4f4d\u60a3\u8005\u62d2\u7edd\u4e86\u5316\u7597\uff0c\u4e0d\u8fc7\u63a5\u53d7\u4e86\u6307\u9aa8\u5207\u9664\u624b\u672f\uff0c\u4e00\u5e74\u540e\uff0c\u4ed6\u6ca1\u6709\u51fa\u73b0\u4efb\u4f55\u660e\u663e\u7684\u75c7\u72b6\uff0c\u4e14\u53f3\u624b\u529f\u80fd\u826f\u597d\u3002<\/p>\n\n\n\n<p>\u65e9\u671f\u7684\u4e00\u4e9b\u7814\u7a76\u8fd8\u663e\u793a\uff0c<strong>\u80ba\u764c\u3001\u4e73\u817a\u764c\u8f83\u5bb9\u6613\u8f6c\u79fb\u5230\u624b\u6307\uff0c\u800c\u6ccc\u5c3f\u751f\u6b96\u7cfb\u7edf\u80bf\u7624\u3001\u80c3\u80a0\u9053\u80bf\u7624\u5219\u66f4\u5bb9\u6613\u8f6c\u79fb\u5230\u811a\u8dbe<\/strong>\u3002<strong>\u4e14\u76f8\u6bd4\u4e8e\u5973\u6027\uff0c\u80a2\u7aef\u8f6c\u79fb\u66f4\u5bb9\u6613\u51fa\u73b0\u5728\u7537\u6027\u60a3\u8005\u8eab\u4e0a<\/strong>\u3002\u5982\u679c\u5468\u56f4\u6709\u4eba\u624b\u90e8\u548c\u811a\u90e8\u533a\u57df\u51fa\u73b0\u6301\u7eed\u80bf\u80c0\u548c\u75bc\u75db\u65f6\uff0c\u4e14\u6ca1\u6709\u5916\u4f24\u56e0\u7d20\uff0c\u6297\u751f\u7d20\u3001\u4e00\u822c\u9547\u75db\u836f\u6cbb\u7597\u4e5f\u6ca1\u6709\u6548\u679c\u65f6\uff0c\u6216\u8bb8\u53ef\u4ee5\u8003\u8651X\u5149\u7247\u7b5b\u67e5\u3002<\/p>\n\n\n\n<p class=\"has-text-align-center has-medium-font-size\"><strong><mark style=\"background-color:rgba(0, 0, 0, 0);\"><span style=\"font-size: 24px; text-decoration: overline; caret-color: rgb(8,124,186); color: rgb(8,124,186);\"><strong><br><br>\u6709\u5e0c\u671b\u7684\u524d\u666f<\/strong><\/span><\/mark><\/strong><\/p>\n\n\n\n<p>\u9664\u4e86\u9aa8\u8f6c\u79fb\u4e4b\u5916\uff0c\u6839\u636e\u7f8e\u56fd\u56fd\u5bb6\u764c\u75c7\u7814\u7a76\u6240\uff08NCI\uff09\u5b98\u7f51\u7684\u6570\u636e\uff0c<strong>\u80bf\u7624\u5f88\u5bb9\u6613\u8f6c\u79fb\u7684\u90e8\u4f4d\u8fd8\u5305\u62ec\u80ba\u90e8\u548c\u809d\u810f\u7b49<\/strong>\u3002\u8fd9\u5176\u5b9e\u5e76\u4e0d\u662f\u5076\u7136\uff0c\u4e00\u4e9b\u73b0\u4ee3\u7684\u7814\u7a76\u5df2\u7ecf\u6839\u636e\u8fd9\u4e9b\u5668\u5b98\u7684\u89e3\u5256\u5b66\u7279\u70b9\uff0c\u7ed9\u51fa\u4e86\u6bd4\u8f83\u53ef\u9760\u7684\u4f9d\u636e\u3002<\/p>\n\n\n\n<p>\u6bd4\u5982\u809d\u810f\uff0c\u8fd9\u91cc\u6709\u7740\u4e30\u5bcc\u3001\u66f2\u6298\u7684\u6bdb\u7ec6\u8840\u7ba1\uff0c\u8840\u7ba1\u6e17\u900f\u6027\u5f88\u5f3a\uff0c\u4e14\u4f1a\u540c\u65f6\u63a5\u53d7\u542b\u6c27\u7684\u52a8\u8109\u8840\uff0c\u548c\u6765\u81ea\u80c3\u80a0\u9053\u7684\u3001\u5bcc\u542b\u8425\u517b\u7269\u8d28\u7684\u95e8\u9759\u8109\u8840\u3002\u8fd9\u4e9b\u90fd\u4e3a\u80bf\u7624\u63d0\u4f9b\u4e86\u6709\u5229\u7684\u5b9a\u6b96\u6761\u4ef6\u3002\u800c\u80ba\u90e8\u662f\u9759\u8109\u8840\u56de\u6d41\u3001\u805a\u96c6\u7684\u5668\u5b98\uff0c\u4e5f\u662f\u5f88\u591a\u8fdb\u5165\u9759\u8109\u7684\u764c\u7ec6\u80de\u9996\u5148\u5230\u8fbe\u7684\u5668\u5b98\uff0c\u8fd9\u91cc\u7684\u6bdb\u7ec6\u8840\u7ba1\u4f1a\u62e6\u4f4f\u5f88\u591a\u764c\u7ec6\u80de\u3002<\/p>\n\n\n\n<p>\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u80bf\u7624\u5728\u9aa8\u9ad3\u4e2d\u5b9a\u6b96\u4f1a\u66f4\u52a0\u590d\u6742\u3002\u4e00\u65b9\u9762\uff0c\u9aa8\u9abc\u4e2d\u786e\u5b9e\u5b58\u5728\u4e00\u4e9b\u7279\u522b\u7684\u7ed3\u6784\uff0c\u5bfc\u81f4\u764c\u7ec6\u80de\u7684\u6ede\u7559\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u5f88\u591a\u7814\u7a76\u53d1\u73b0\uff0c\u7531\u4e8e\u9aa8\u9abc\u662f\u4e00\u4e2a\u52a8\u6001\u53d8\u5316\u7684\u5668\u5b98\u2014\u2014\u4e00\u76f4\u5904\u4e8e\u5438\u6536\u65e7\u9aa8\u9abc\u548c\u5f62\u6210\u65b0\u9aa8\u9abc\u7684\u8fc7\u7a0b\uff0c<strong>\u5176\u4e2d\u7684\u5206\u6ccc\u4e00\u4e9b\u751f\u7269\u5206\u5b50\u80fd\u4fc3\u8fdb\u4fc3\u8fdb\u764c\u7ec6\u80de\u7684\u751f\u5b58<\/strong>\u3002\u6700\u4e3a\u5173\u952e\u7684\u662f\uff0c\u4e00\u4e9b\u7814\u7a76\u4eba\u5458\u53d1\u73b0\u9aa8\u9abc\u53ef\u80fd\u4f1a\u201c\u5438\u5f15\u201d\u5f88\u591a\u80bf\u7624\u7684\u5b9a\u6b96\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"400\" src=\"https:\/\/www.huanqiukexue.com\/wp-content\/uploads\/2025\/11\/wechat_image_2-9.jpg\" alt=\"\" class=\"wp-image-3400\" srcset=\"https:\/\/www.huanqiukexue.com\/wp-content\/uploads\/2025\/11\/wechat_image_2-9.jpg 600w, https:\/\/www.huanqiukexue.com\/wp-content\/uploads\/2025\/11\/wechat_image_2-9-300x200.jpg 300w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><\/figure>\n\n\n\n<p><span style=\"color: rgb(153, 153, 153); font-size: 16px; letter-spacing: 1px;\">\u56fe\u7247\u6765\u6e90\uff1aUnsplash<\/span><\/p>\n\n\n\n<p>2006\u5e74\uff0c\u4e00\u9879\u53d1\u8868\u4e8e<a target=\"_blank\" href=\"https:\/\/www.nature.com\/articles\/nature04524\" rel=\"noreferrer noopener\">\u300a\u81ea\u7136\u300b<\/a>\uff08<em>Nature<\/em>\uff09\u7684\u7814\u7a76\u5173\u6ce8\u4e86\u8c03\u63a7\u9aa8\u9abc\u751f\u957f\u5173\u952e\u7684\u7ec6\u80de\u56e0\u5b50RANKL\u548cRANK\u53d7\u4f53\u901a\u8def\uff0c<strong>\u5e76\u53d1\u73b0\u5f88\u591a\u80bf\u7624\u4f1a\u8868\u8fbeRANK\u53d7\u4f53\uff0c\u8fd9\u4f1a\u4fc3\u8fdb\u5b83\u4eec\u7684\u9aa8\u8fc1\u79fb<\/strong>\u3002<\/p>\n\n\n\n<p>\u4e00\u4e2a\u4e25\u5cfb\u7684\u60c5\u51b5\u662f\uff0c\u9aa8\u8f6c\u79fb\u6700\u5e38\u89c1\u7684\u662f\u524d\u5217\u817a\u764c\u3001\u4e73\u817a\u764c\u548c\u80ba\u764c\uff0c\u800c\u8fd9\u4e9b\u764c\u75c7\u5982\u4eca\u5df2\u7ecf\u662f\u6700\u5e38\u89c1\u7684\u6076\u6027\u80bf\u7624\uff0c\u53d1\u75c5\u7387\u548c\u6b7b\u4ea1\u7387\u5747\u5f88\u9ad8\u3002\u4f46\u8fd8\u6709\u4e00\u4e9b\u597d\u6d88\u606f\uff0c\u76ee\u524d\u5df2\u6709\u4e00\u4e9b\u5173\u952e\u7684\u836f\u7269\u53ef\u4ee5\u901a\u8fc7\u8fd9\u6761\u901a\u8def\uff0c\u6765\u51cf\u8f7b\u80bf\u7624\u5bf9\u9aa8\u9abc\u7684\u7834\u574f\u3002<\/p>\n\n\n\n<p>\u6b64\u524d\uff0c\u5f53\u80bf\u7624\u53d1\u751f\u9aa8\u8f6c\u79fb\u540e\u53ea\u80fd\u91c7\u7528\u59d1\u606f\u6cbb\u7597\u7684\u65b9\u6cd5\uff0c<strong>\u5982\u4eca\u5df2\u6709\u66f4\u52a0\u591a\u6837\u5316\u7684\u6cbb\u7597\u624b\u6bb5<\/strong>\uff0c\u5305\u62ec\u4e0d\u65ad\u4f18\u5316\u7684\u653e\u7597\u3001\u5316\u7597\uff0c\u4ee5\u53ca\u514d\u75ab\u68c0\u6d4b\u70b9\u6291\u5236\u5242\uff08\u5728\u4e0d\u540c\u7684\u9aa8\u8f6c\u79fb\u80bf\u7624\u4e2d\uff0c\u6548\u679c\u5b58\u5728\u5f88\u5927\u5dee\u5f02\uff09\u3002\u5177\u4f53\u8fd9\u4e9b\u7597\u6cd5\u5982\u4f55\u4e0e\u4fdd\u62a4\u9aa8\u9abc\u836f\u7269\u7ed3\u5408\u4f7f\u7528\uff0c\u8fd8\u9700\u8981\u4e13\u4e1a\u7684\u533b\u751f\u56e2\u961f\u6839\u636e\u60a3\u8005\u7684\u60c5\u51b5\u6765\u5b9a\u5236\u6cbb\u7597\u65b9\u6848\u3002<\/p>\n\n\n\n<p class=\"has-text-align-center has-medium-font-size\"><strong><mark style=\"background-color:rgba(0, 0, 0, 0);\"><span style=\"font-size: 24px; text-decoration: overline; caret-color: rgb(8,124,186); color: rgb(8,124,186);\"><strong><br><br>\u5371\u9669\u7684\u201c\u6f5c\u4f0f\u201d<\/strong><\/span><\/mark><\/strong><\/p>\n\n\n\n<p>\u5bf9\u9aa8\u8f6c\u79fb\u7684\u7814\u7a76\u4e5f\u5728\u7ee7\u7eed\u63a8\u8fdb\u3002\u4e00\u4e9b\u524d\u6cbf\u7814\u7a76\u6b63\u5728\u901a\u8fc7\u6291\u5236\u4e00\u4e9b\u80fd\u5e2e\u52a9\u764c\u7ec6\u80de\u8f6c\u79fb\u7684\u5206\u5b50\u6765\u7f13\u89e3\u80bf\u7624\uff0c\u751a\u81f3\u6e05\u9664\u8f6c\u79fb\u7684\u80bf\u7624\u7ec6\u80de\u3002\u6bd4\u5982\u53bb\u5e74\u4e00\u9879\u53d1\u8868\u4e8e<a target=\"_blank\" href=\"https:\/\/www.hopkinsmedicine.org\/news\/newsroom\/news-releases\/2024\/10\/experimental-cancer-drug-eliminates-bone-metastases-caused-by-breast-cancer-in-lab-models\" rel=\"noreferrer noopener\">\u300a\u764c\u75c7\u5feb\u62a5\u300b<\/a>\uff08<em>Cancer Letters<\/em>\uff09\u7684\u7814\u7a76\u663e\u793a\uff0c\u5728\u5c0f\u9f20\u4e2d\uff0c\u4e00\u79cd\u540d\u4e3aRK-33\u7684\u5206\u5b50\u901a\u8fc7\u4f5c\u7528\u4e8e\u4fc3\u8fdb\u80bf\u7624\u751f\u957f\u7684\u5173\u952e\u86cb\u767d\u8d28\uff0c\u51e0\u4e4e\u80fd\u6e05\u9664\u6240\u6709\u7684\u4e73\u817a\u764c\u9aa8\u8f6c\u79fb\u80bf\u7624\u3002<\/p>\n\n\n\n<p>\u4eca\u5e745\u6708\u4e00\u9879\u53d1\u8868\u4e8e<a target=\"_blank\" href=\"https:\/\/www.mdanderson.org\/newsroom\/research-newsroom\/study-identifies-a-new-driver-and-therapeutic-vulnerability-of-bone-metastasis.h00-159776445.html\" rel=\"noreferrer noopener\">\u300a\u79d1\u5b66\u00b7\u8f6c\u5316\u533b\u5b66\u300b<\/a>\uff08<em>Science Translational Medicine<\/em>\uff09\u7684\u7814\u7a76\u5219\u53d1\u73b0\u4e00\u79cd\u5173\u952e\u7684\u86cb\u767d\u8d28\u80fd\u4fc3\u8fdb\u9aa8\u8f6c\u79fb\uff0c\u800c\u6572\u9664\u80bf\u7624\u4e2d\u7684\u8fd9\u4e00\u57fa\u56e0\uff0c\u53ef\u4ee5\u5b8c\u5168\u963b\u6b62\u9aa8\u8f6c\u79fb\u3002<\/p>\n\n\n\n<p>\u8fd1\u5e74\u6765\uff0c\u5f88\u591a\u7814\u7a76\u4eba\u5458\u4e5f\u5728\u5173\u6ce8\u9aa8\u8f6c\u79fb\u4e2d\u7684\u53e6\u4e00\u4e2a\u73b0\u8c61\uff1a<strong>\u9aa8\u8f6c\u79fb\u7624\u7684\u4f11\u7720<\/strong>\u3002\u5f53\u9aa8\u8f6c\u79fb\u7624\u5728\u9aa8\u9abc\u8868\u9762\u8fdb\u5165\u5230\u4f11\u7720\u72b6\u6001\u540e\uff0c<strong>\u4e14\u53ef\u4ee5\u4fdd\u6301\u8fd9\u4e2a\u72b6\u6001\u957f\u8fbe\u5341\u591a\u5e74\u7684\u65f6\u95f4<\/strong>\u3002\u8fd9\u4e00\u65f6\u671f\uff0c\u5373\u4fbf\u662f\u901a\u8fc7\u4e00\u4e9b\u653e\u5c04\u5b66\u7684\u624b\u6bb5\u4e5f\u65e0\u6cd5\u68c0\u6d4b\u5230\u5b83\u4eec\u3002\u8fd9\u4e5f\u662f\u4e00\u4e9b\u80bf\u7624\u6062\u590d\u540e\uff0c\u7ecf\u8fc7\u591a\u5e74\u7684\u65f6\u95f4\uff0c\u53c8\u590d\u53d1\u7684\u539f\u56e0\u3002\u800c\u8fd9\u4e9b\u80bf\u7624\u4e3a\u4ec0\u4e48\u4f1a\u88ab\u91cd\u65b0\u5524\u9192\uff0c\u4e5f\u662f\u5f53\u524d\u7684\u4e00\u4e2a\u7814\u7a76\u70ed\u70b9\u3002<\/p>\n\n\n\n<span style=\"color: rgb(153, 153, 153); font-size: 16px; letter-spacing: 1px;\">\u53c2\u8003\u94fe\u63a5\uff1a<br>\nhttps:\/\/www.livescience.com\/health\/cancer\/weird-swelling-of-mans-fingers-and-toes-revealed-cancer-had-completely-replaced-the-bones-with-lesions<br>\nhttps:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC2728313\/<br>\nhttps:\/\/perspectivesinmedicine.cshlp.org\/content\/10\/3\/a037259.full.pdf?<br>\nhttps:\/\/link.springer.com\/article\/10.1186\/s13046-022-02520-0<br>\nhttps:\/\/journals.physiology.org\/doi\/full\/10.1152\/physiol.00020.2022<br>\nhttps:\/\/www.nature.com\/articles\/s41593-025-02064-4<br>\nhttps:\/\/www.nature.com\/articles\/nature04524<\/span>\n","protected":false},"excerpt":{"rendered":"<p>\u7834\u574f\u9aa8\u9abc\u7684\u80bf\u7624<\/p>\n","protected":false},"author":3,"featured_media":3400,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8,5],"tags":[114],"class_list":["post-3403","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lead","category-health","tag-114"],"_links":{"self":[{"href":"https:\/\/www.huanqiukexue.com\/index.php?rest_route=\/wp\/v2\/posts\/3403","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.huanqiukexue.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.huanqiukexue.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.huanqiukexue.com\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.huanqiukexue.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3403"}],"version-history":[{"count":1,"href":"https:\/\/www.huanqiukexue.com\/index.php?rest_route=\/wp\/v2\/posts\/3403\/revisions"}],"predecessor-version":[{"id":3404,"href":"https:\/\/www.huanqiukexue.com\/index.php?rest_route=\/wp\/v2\/posts\/3403\/revisions\/3404"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.huanqiukexue.com\/index.php?rest_route=\/wp\/v2\/media\/3400"}],"wp:attachment":[{"href":"https:\/\/www.huanqiukexue.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3403"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.huanqiukexue.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3403"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.huanqiukexue.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3403"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}