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font-size: 16px; letter-spacing: 1px;\">\u56fe\u7247\u6765\u6e90\uff1aUnsplash+<\/span><\/p>\n\n\n\n<p>\u4e3a\u4e86\u6cbb\u7597\u5984\u60f3\u75c7\uff0c<strong>\u5361\u54c8\u5170\u670d\u7528\u4e86\u5f88\u591a\u7a33\u5b9a\u7cbe\u795e\u75c7\u72b6\u7684\u836f\u7269\uff08\u9f50\u62c9\u897f\u916e\uff09\u548c\u6297\u7126\u8651\u836f\u7269\uff08\u52b3\u62c9\u897f\u6cee\uff09<\/strong>\uff0c\u867d\u7136\u75c7\u72b6\u51cf\u8f7b\uff0c\u4f46\u5979\u5f00\u59cb\u53d8\u5f97\u65e0\u6cd5\u9605\u8bfb\u3001\u8bf4\u8bdd\u56f0\u96be\uff0c\u96be\u4ee5\u56de\u7b54\u95ee\u9898\uff0c\u541e\u54bd\u4e5f\u53d8\u5f97\u5341\u5206\u8d39\u529b\u3002\u4e00\u5207\u4f3c\u4e4e\u5df2\u7ecf\u8d70\u5230\u4e86\u60ac\u5d16\u7684\u8fb9\u7f18\uff0c\u4f46\u5979\u7684\u7236\u6bcd\u5e76\u4e0d\u60f3\u628a\u5979\u9001\u5165\u7cbe\u795e\u75c5\u9662\uff0c\u4ed6\u4eec\u5bb3\u6015\u5c06\u4f1a\u5f7b\u5e95\u5931\u53bb\u5979\u3002<\/p>\n\n\n\n<p>\u597d\u5728\u5947\u8ff9\u51fa\u73b0\u4e86\uff01\u4ed6\u4eec\u9047\u5230\u4e86\u88ab\u540c\u4e8b\u79f0\u4e3a\u201c\u8c6a\u65af\u533b\u751f\u201d\u7684\u795e\u7ecf\u79d1\u533b\u751f\u82cf\u8d6b\u5c14\u00b7\u7eb3\u8d3e\u5c14\u533b\u751f\uff08Dr. Souhel Najjar\uff09\u3002\u4ed6\u4e5f\u662f\u7ebd\u7ea6\u5927\u5b66\u533b\u5b66\u4e2d\u5fc3\u7684\u795e\u7ecf\u75c5\u7406\u5b66\u5bb6\u548c\u766b\u75eb\u75c5\u5b66\u5bb6\u3002\u7eb3\u8d3e\u5c14\u67e5\u770b\u5361\u54c8\u5170\u7684\u68c0\u6d4b\u62a5\u544a\u540e\uff0c\u53d1\u73b0\u4e24\u6b21\u8170\u690e\u7a7f\u523a\u90fd\u663e\u793a\uff0c\u5979\u8111\u810a\u6db2\u4e2d\u7684\u767d\u7ec6\u80de\u8ba1\u6570\u8fc7\u9ad8\uff0c\u8fd9\u8bf4\u660e\u5979\u51fa\u73b0\u4e86\u8111\u80bf\u80c0\u3002<\/p>\n\n\n\n<p>\u968f\u540e\uff0c\u8fd9\u4f4d\u533b\u751f\u8ba9\u5361\u54c8\u5170\u5728\u7eb8\u4e0a\u753b\u4e00\u4e2a\u949f\u3002\u867d\u7136\u7591\u60d1\uff0c\u4f46\u5361\u54c8\u5170\u8fd8\u662f\u7167\u505a\u4e86\uff0c\u800c\u5979\u753b\u51fa\u7684\u949f\u9762\u8ba9\u6240\u6709\u4eba\u90fd\u5012\u5438\u4e00\u53e3\u51c9\u6c14\u2014\u2014<strong>\u949f\u9762\u4e0a\u6240\u6709\u6570\u5b57\u90fd\u51fa\u73b0\u5728\u949f\u7684\u53f3\u8fb9<\/strong>\u3002\u6839\u636e\u8fd9\u4e9b\u7ebf\u7d22\u548c\u5361\u54c8\u5170\u7684\u591a\u79cd\u75c7\u72b6\uff0c\u7eb3\u8d3e\u5c14\u8ba4\u4e3a\u5361\u54c8\u5170\uff08\u63a7\u5236\u8eab\u4f53\u5de6\u4fa7\uff09\u7684\u53f3\u8111\u51fa\u73b0\u4e86\u708e\u75c7\uff0c\u5177\u4f53\u662f\u4e00\u79cd<strong>\u81ea\u8eab\u514d\u75ab\u6027\u8111\u708e<\/strong>\u3002\u6216\u8005\u8bf4\uff0c\u5979\u53f3\u8111\u4e2d\u5b58\u5728\u4e00\u79cd\u5f02\u5e38\u7684\u3001\u653b\u51fb\u81ea\u8eab\u7684\u6297\u4f53\uff0c\u5f15\u53d1\u4e86\u8111\u80bf\u80c0\u3002<\/p>\n\n\n\n<p class=\"has-text-align-center has-medium-font-size\"><strong><mark style=\"background-color:rgba(0, 0, 0, 0);\"><span style=\"font-size: 24px; 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font-size: 16px; letter-spacing: 1px;\">\u5361\u54c8\u5170\u7684\u4f4f\u9662\u7167\u7247\u548c\u8111\u90e8\u7684\u60c5\u51b5 \u56fe\u7247\u6765\u6e90\u4e8e<a target=\"_blank\" href=\"https:\/\/iocdf.org\/wp-content\/uploads\/2023\/08\/Autoimmune-OCD_Can-Infections-Trigger-Autoimmune-OCD-and-How-can-this-be-diagnosed-and-treated.pdf\" rel=\"noreferrer noopener\">iocdf.org<\/a><\/span><\/p>\n\n\n\n<p>\u786e\u8bca\u540e\uff0c\u5361\u54c8\u5170\u5f88\u5feb\u63a5\u53d7\u4e86<strong>\u7c7b\u56fa\u9187\u7ed9\u836f\u3001\u8840\u6d46\u7f6e\u6362\u548c\u9759\u8109\u6ce8\u5c04\u514d\u75ab\u7403\u86cb\u767d\u7684\u8054\u5408\u6cbb\u7597<\/strong>\u3002\u5979\u7684\u75c5\u60c5\u6162\u6162\u597d\u8f6c\uff0c\u6700\u7ec8\u5979\u7684\u8ba4\u77e5\u548c\u8eab\u4f53\u5b8c\u5168\u6062\u590d\u4e86\u3002\u76f8\u6bd4\u4e8e\u5f88\u591a\u5c31\u7b97\u5eb7\u590d\u540e\u4ecd\u6709\u4e25\u91cd\u6216\u8005\u8f7b\u5fae\u8ba4\u77e5\u969c\u788d\u7684\u4eba\uff08\u5360\u6bd4\u5927\u6982\u662f45%\uff09\uff0c\u8fd9\u4e5f\u53ef\u4ee5\u79f0\u5f97\u4e0a\u4e00\u4e2a\u5947\u8ff9\u3002<\/p>\n\n\n\n<p>\u5982\u679c\u4f60\u4ece\u5361\u54c8\u5170\u7ecf\u5386\u770b\u51fa\uff0c\u8fd9\u79cd\u75c5\u7684\u51fa\u73b0\u4f3c\u4e4e\u6ca1\u6709\u5f81\u5146\uff0c\u53ef\u80fd\u4e3b\u8981\u5a01\u80c1\u5e74\u8f7b\u4eba\uff0c\u90a3\u53ef\u4ee5\u8bf4\u4f60\u7684\u76f4\u89c9\u5341\u5206\u51c6\u786e\u3002\u636e\u6089\uff0c<strong>\u8fd9\u79cd\u75be\u75c5\u4e3b\u8981\u5f71\u54cd20\u81f330\u591a\u5c81\u7684\u4eba\uff0c\u5728\u513f\u7ae5\u548c\u9752\u5c11\u5e74\u4e2d\u5341\u5206\u5e38\u89c1\uff0c\u800c\u6700\u5c0f\u7684\u60a3\u8005\u53ea\u670921\u4e2a\u6708\u5927<\/strong>\u3002\u800c\u6839\u636e\u4e00\u9879\u7eb3\u5165633\u4f8b\u60a3\u8005\u7684\u7efc\u8ff0\u6027\u7814\u7a76\uff0c\u8be5\u75c5\u7684\u4e2d\u4f4d\u53d1\u75c5\u5e74\u9f84\u4e3a22.6\u5c81\u3002\u53e6\u5916\uff0c\u8fd9\u79cd\u75be\u75c5\u4e3b\u8981\u4f1a\u5a01\u80c1\u5973\u6027\uff0c\u7537\u5973\u7684\u6bd4\u4f8b\u5927\u7ea6\u4e3a1:4\u3002<\/p>\n\n\n\n<p>\u7ed3\u54082022\u5e74\u53d1\u5e03\u7684\u4e00\u4e9b\u75c5\u4f8b\u62a5\u544a\uff0c\u8be5\u75be\u75c5\u4f3c\u4e4e\u4f1a\u7a81\u7136\u88ad\u51fb\u3002\u6bd4\u5982\uff0c\u6839\u636e<em>Acta Epileptologica<\/em>\u6742\u5fd7\u4e0a\u7684\u75c5\u4f8b\u62a5\u544a\uff0c<strong>\u4e00\u4f4d11\u5c81\u5973\u5b69\u5728\u5267\u70c8\u8fd0\u52a8\u540e\u51fa\u73b0\u4e0a\u8179\u90e8\u75bc\u75db<\/strong>\uff0c\u7d27\u63a5\u7740\u662f\u4e00\u7cfb\u5217\u75c7\u72b6\uff0c\u5305\u62ec\u808c\u8089\u65e0\u529b\u3001\u6655\u53a5\u3001\u5c3f\u5931\u7981\u3001\u5455\u5410\uff0c\u4ee5\u53ca\u5934\u75db\u53d1\u4f5c\u548c\u70e6\u8e81\u4e0d\u5b89\u7b49\u3002\u6700\u7ec8\u5979\u4e5f\u786e\u8bca\u4e86\u6297NMDAR\u8111\u708e\u3002<\/p>\n\n\n\n<p>\u53e6\u4e00\u4e2a\u75c5\u4f8b\u662f\u4e00\u4f4d24\u5c81\u5973\u6027\uff0c<strong>\u5979\u56e0\u4e3a\u6025\u6027\u610f\u8bc6\u6a21\u7cca\u800c\u6025\u8bca\u5165\u9662<\/strong>\u3002\u968f\u7740\u610f\u8bc6\u8fc5\u901f\u6076\u5316\uff0c\u5979\u5f00\u59cb\u51fa\u73b0\u541e\u54bd\u56f0\u96be\u3001\u547c\u5438\u8870\u7aed\u548c\u4e25\u91cd\u7684\u5fc3\u52a8\u8fc7\u7f13\u3002\u5165\u9662\u7b2c23\u5929\uff0c\u5979\u7ecf\u7531\u8111\u90e8\u78c1\u5171\u632f\u6210\u50cf\u68c0\u6d4b\uff0c\u786e\u8bca\u4e86\u6297NMDAR\u8111\u708e\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"277\" src=\"https:\/\/www.huanqiukexue.com\/wp-content\/uploads\/2026\/02\/wechat_image_2-2.jpg\" alt=\"\" class=\"wp-image-3682\" srcset=\"https:\/\/www.huanqiukexue.com\/wp-content\/uploads\/2026\/02\/wechat_image_2-2.jpg 600w, https:\/\/www.huanqiukexue.com\/wp-content\/uploads\/2026\/02\/wechat_image_2-2-300x139.jpg 300w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><\/figure>\n\n\n\n<p><span style=\"color: rgb(153, 153, 153); font-size: 16px; letter-spacing: 1px;\">\u60a3\u8005\u7684\u6d77\u9a6c\u4e0d\u5bf9\u79f0\uff0c\u51fa\u73b0\u4e86\u708e\u75c7 \u56fe\u7247\u6765\u6e90\u4e8e<a target=\"_blank\" href=\"https:\/\/link.springer.com\/article\/10.1186\/s41983-022-00512-7\" rel=\"noreferrer noopener\">\u8bba\u6587<\/a><\/span><\/p>\n\n\n\n<p>\u7c7b\u4f3c\u7684\u75c5\u4f8b\u8fd8\u5728\u9646\u7eed\u51fa\u73b0\u3002\u4f46\u5e78\u8fd0\u7684\u662f\uff0c\u8fd9\u79cd\u75be\u75c5\u4ecd\u7136\u662f\u4e00\u79cd\u7f55\u89c1\u75c5\uff0c<strong>\u6bcf\u5e74\u5f71\u54cd\u7ea6\u767e\u4e07\u5206\u4e4b\u4e00\u7684\u4eba<\/strong>\u3002<\/p>\n\n\n\n<p>\u4e0d\u8fc7\u8fd9\u79cd\u75be\u75c5\u7684\u6cbb\u7597\u548c\u8bca\u65ad\uff0c\u5982\u4eca\u4ecd\u7136\u4e0d\u5bb9\u4e50\u89c2\u3002\u57282009\u5e74\u65f6\uff0c\u7eb3\u8d3e\u5c14\u66fe\u4f30\u8ba1\u5f53\u65f6\u5927\u7ea6\u670990%\u8fd9\u79cd\u75be\u75c5\u7684\u60a3\u8005\u5e76\u672a\u786e\u8bca\uff0c\u7ea680%\u7684\u60a3\u8005\u4f1a\u766b\u75eb\u53d1\u4f5c\u3002\u5176\u4e2d\u8bb8\u591a\u4eba\u53ef\u80fd\u4f1a\u88ab\u9001\u8fdb\u7cbe\u795e\u75c5\u9662\u6216\u8005\u7597\u517b\u9662\uff0c\u65e0\u6cd5\u5f97\u5230\u4efb\u4f55\u6cbb\u7597\u3002<\/p>\n\n\n\n<p>\u4e0d\u8fc7\uff0c\u968f\u7740\u68c0\u6d4b\u6280\u672f\u7684\u53d1\u5c55\uff0c\u68c0\u6d4b\u60a3\u8005\u81ea\u8eab\u8840\u6e05\u6216\u8111\u810a\u6db2\u4e2d\u7684\u6297NMDAR\u7684\u81ea\u8eab\u6297\u4f53\uff0c\u53ef\u4ee5\u8f83\u9ad8\u5730\u63d0\u9ad8\u8bca\u65ad\u7387\u3002<strong>\u8111\u810a\u6db2\u68c0\u6d4b\u901a\u5e38\u66f4\u654f\u611f\u3001\u66f4\u7279\u5f02\uff0c\u4e5f\u662f\u8fd9\u79cd\u75be\u75c5\u8bca\u65ad\u7684\u91d1\u6807\u51c6<\/strong>\u3002<\/p>\n\n\n\n<p>\u4f46\u9488\u5bf9\u8fd9\u4e9b\u6709\u5bb3\u7684\u81ea\u8eab\u6297\u4f53\uff0c\u5f00\u521b\u51fa\u8fd9\u79cd\u75be\u75c5\u7684\u7279\u6548\u836f\uff0c\u5e76\u4e0d\u662f\u4e00\u4ef6\u5bb9\u6613\u7684\u4e8b\u30022009\u5e74\u65f6\uff0c\u5361\u54c8\u5170\u4f7f\u7528\u7684\u4e09\u79cd\u7597\u6cd5\uff0c\u5305\u62ec\u7c7b\u56fa\u9187\u7ed9\u836f\u3001\u8840\u6d46\u7f6e\u6362\u548c\u9759\u8109\u6ce8\u5c04\u514d\u75ab\u7403\u86cb\u767d\u7684\u8054\u5408\u6cbb\u7597\uff0c\u5f53\u524d\u4f9d\u65e7\u662f\u4e00\u7ebf\u7684\u6cbb\u7597\u65b9\u6cd5\u3002\u800c\u5f53\u5b83\u4eec\u5931\u6548\u65f6\uff0c<strong>\u60a3\u8005\u5c31\u9700\u8981\u91c7\u7528\u4e8c\u7ebf\u6cbb\u7597\u65b9\u6848\uff0c\u5305\u62ec\u5229\u59a5\u6614\u5355\u6297\u548c\u73af\u78f7\u9170\u80fa<\/strong>\u3002\u8fd9\u4e24\u79cd\u836f\u7269\u5747\u53ef\u4ee5\u901a\u8fc7\u9776\u5411B\u7ec6\u80de\u6765\u9650\u5236\u81ea\u8eab\u6297\u4f53\u7684\u4ea7\u751f\u3002<\/p>\n\n\n\n<p>\u8fd1\u5e74\u6765\uff0c\u4e00\u4e9b\u7814\u7a76\u53d1\u73b0\u51e0\u4e4e\u4e00\u534a\u7684\u75c5\u4f8b\u90fd\u548c\u80bf\u7624\u6709\u5173\uff0c<strong>\u7279\u522b\u662f\u5375\u5de2\u7578\u80ce\u7624<\/strong>\u3002\u5728\u6cbb\u7597\u65f6\uff0c\u53ca\u65f6\u5207\u9664\u80bf\u7624\u5c06\u80fd\u5e2e\u52a9\u60a3\u8005\u6539\u5584\u75c7\u72b6\uff0c\u5e76\u964d\u4f4e\u8fd9\u79cd\u75be\u75c5\u590d\u53d1\u7684\u98ce\u9669\u3002<\/p>\n\n\n\n<p class=\"has-text-align-center has-medium-font-size\"><strong><mark style=\"background-color:rgba(0, 0, 0, 0);\"><span style=\"font-size: 24px; text-decoration: overline; caret-color: rgb(8,124,186); color: rgb(8,124,186);\"><strong><br><br>\u66f4\u591a\u7684\u7814\u7a76\u548c\u6cbb\u7597<\/strong><\/span><\/mark><\/strong><\/p>\n\n\n\n<p>NMDAR \uff0c\u4e5f\u5c31\u662fNMDA\u53d7\u4f53\uff0c\u5176\u5b9e\u662f\u4e00\u79cd<strong>\u5174\u594b\u6027\u7684\u8c37\u6c28\u9178\u95e8\u63a7\u79bb\u5b50\u901a\u9053<\/strong>\uff0c\u5e7f\u6cdb\u5b58\u5728\u4e8e\u795e\u7ecf\u7a81\u89e6\u7684\u540e\u819c\u4e0a\uff0c\u5bf9\u795e\u7ecf\u4fe1\u53f7\u7684\u7a81\u89e6\u4f20\u9012\u3001\u7a81\u89e6\u53ef\u5851\u6027\u548c\u9ad8\u7ea7\u8ba4\u77e5\u529f\u80fd\uff08\u5305\u62ec\u8bb0\u5fc6\u548c\u5b66\u4e60\u7b49\uff09\u81f3\u5173\u91cd\u8981\u3002<\/p>\n\n\n\n<p>\u8fd9\u79cd\u53d7\u4f53\u4e5f\u662f\u4e00\u4e2a\u9700\u4e24\u628a\u201c\u94a5\u5319\u201d\u624d\u80fd\u6253\u5f00\u7684\u201c\u9501\u201d\uff0c\u4e00\u4e2a\u662f\u94a5\u5319\u662f\u8c37\u6c28\u9178\uff0c\u53e6\u4e00\u4e2a\u662f\u7518\u6c28\u9178\u6216\u8005\u662fD-\u4e1d\u6c28\u9178\uff0c<strong>\u5b83\u4eec\u5206\u522b\u7ed3\u5408\u5728\u53d7\u4f53\u4e0a\u7684GluN2\u4e9a\u57fa\u548cGluN1\u4e9a\u57fa<\/strong>\u3002\u5f53\u9501\u88ab\u6253\u5f00\u540e\uff0c\u795e\u7ecf\u5143\u5185\u5916\u7684\u79bb\u5b50\u4f1a\u5feb\u901f\u6d41\u52a8\u5e76\u5f62\u6210\u52a8\u4f5c\u7535\u4f4d\uff0c\u968f\u7740\u795e\u7ecf\u5143\u5f00\u59cb\u5174\u594b\uff0c\u53c8\u80fd\u6fc0\u6d3b\u4e0b\u6e38\u7684\u795e\u7ecf\u4fe1\u53f7\u3002<\/p>\n\n\n\n<p>\u5728\u795e\u7ecf\u5143\u4e2d\uff0c\u60f3\u8981\u5c06\u8fd9\u628a\u201c\u9501\u201d\u56fa\u5b9a\u5728\u7a81\u89e6\u540e\u819c\u4e0a\uff0c\u8fd8\u9700\u8981\u4e00\u79cd\u5173\u952e\u7684\u53d7\u4f53EphB2\u3002<strong>EphB2\u88ab\u86cb\u767dEphrin\u6fc0\u6d3b\u540e\uff0c\u4e0eGluN2\u4e9a\u57fa\u7684\u7ed3\u5408\u4f1a\u66f4\u52a0\u7a33\u5b9a<\/strong>\uff0c\u4ece\u800c\u66f4\u597d\u5730\u5c06NMDAR\u56fa\u5b9a\u5728\u7a81\u89e6\u540e\u819c\u3002<\/p>\n\n\n\n<p>\u4e00\u65e6\u8fd9\u6837\u7684\u72b6\u6001\u88ab\u7834\u574f\uff0c\u5c31\u4f1a\u5f15\u53d1\u4e0a\u8ff0\u7684\u591a\u79cd\u4e25\u91cd\u75c7\u72b6\u3002\u90a3\u4e48\u5b83\u4f1a\u5982\u4f55\u88ab\u4eba\u4f53\u81ea\u8eab\u7684\u6297\u4f53\u7834\u574f\u5462\uff1f 2018\u5e74\uff0c\u4e00\u7bc7\u7cfb\u7edf\u6027\u7684\u7efc\u8ff0\u6c47\u603b\u4e86633\u4f8b\u6297NMDAR\u8111\u708e\u60a3\u8005\u7684\u4e34\u5e8a\u75c7\u72b6\uff0c\u53d1\u73b0\u8fd9\u4e9b\u53ef\u4ee5\u7a7f\u8fc7\u8840\u8111\u5c4f\u969c\u7684\u81f4\u75c5\u6297\u4f53\uff0c\u4e3b\u8981\u4f1a\u9776\u5411NMDA\u53d7\u4f53\u7684GluN1\u4e9a\u57fa\uff0c\u8fdb\u800c\u5bfc\u81f4\u8c37\u6c28\u9178\u80fd\u795e\u7ecf\u5143\u7ec6\u80de\u4fe1\u53f7\u4f20\u5bfc\u53d7\u635f\u30021\u670814\u65e5\uff0c\u5728\u4e00\u9879\u53d1\u8868\u4e8e\u300a\u79d1\u5b66\u00b7\u8fdb\u5c55\u300b\uff08<em>Science Advances<\/em>\uff09\u7684\u7814\u7a76\u4e2d\uff0c\u4fc4\u52d2\u5188\u5065\u5eb7\u4e0e\u79d1\u5b66\u5927\u5b66\u7684\u7814\u7a76\u4eba\u5458\u901a\u8fc7\u6784\u5efa\u5c0f\u9f20\u6a21\u578b\uff0c\u6a21\u4eff\u4eba\u7c7b\u4e2d\u7684\u6297NMDAR\u8111\u708e\u3002<\/p>\n\n\n\n<p>\u5f53\u8fd9\u4e9b\u5c0f\u9f20\u51fa\u73b0\u81ea\u8eab\u514d\u75ab\u6027\u8111\u708e\u540e\uff0c\u4ed6\u4eec\u5206\u79bb\u51fa\u4e86\u5c0f\u9f20\u4f53\u5185\u6240\u6709\u7684\u5929\u7136\u6297\u4f53\u548cNMDAR\u7684\u805a\u5408\u7269\uff0c\u5e76\u901a\u8fc7\u8fd1\u539f\u5b50\u7ea7\u522b\u7684\u6210\u50cf\u6280\u672f\uff0c\u63ed\u793a\u4e86<strong>GluN1\u4e9a\u57fa\u7684\u6c28\u57fa\u672b\u7aef\u7ed3\u6784\u57df\uff08ATD\uff09\u662f\u8fd9\u4e9b\u75c5\u7406\u6027\u6297\u4f53\u9776\u5411\u7684\u4e00\u4e2a\u6297\u539f\u201c\u70ed\u70b9\u533a\u57df\u201d<\/strong>\u3002<\/p>\n\n\n\n<p>\u4e0e\u6b64\u540c\u65f6\uff0c\u4ed6\u4eec\u8fd8\u53d1\u73b0\u8fd9\u4e9b\u6297\u4f53\u548cGluN1\u4e9a\u57fa\u7ed3\u5408\u540e\uff0c\u5e76\u4e0d\u4f1a\u6291\u5236\u6574\u4e2a\u53d7\u4f53\uff0c\u800c\u662f\u4f1a\u518d\u8fde\u63a5\u53e6\u4e00\u4e2a\u53d7\u4f53\uff0c<strong>\u8ba9\u8fd9\u4e9b\u53d7\u4f53\u805a\u96c6\u2014\u2014\u8fd9\u79cd\u805a\u96c6\u901a\u5e38\u4f1a\u7834\u574f\u7a81\u89e6\u7ec4\u7ec7<\/strong>\u3002\u800c\u968f\u7740\u805a\u96c6\u4fe1\u53f7\u88ab\u7ec6\u80de\u8bc6\u522b\uff0c\u8fd9\u4e9b\u53d7\u4f53\u4f1a\u88ab\u62c9\u5165\u795e\u7ecf\u5143\u5185\u90e8\uff0c\u5e76\u6700\u7ec8\u88ab\u964d\u89e3\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"357\" src=\"https:\/\/www.huanqiukexue.com\/wp-content\/uploads\/2026\/02\/wechat_image_9.jpg\" alt=\"\" class=\"wp-image-3683\" srcset=\"https:\/\/www.huanqiukexue.com\/wp-content\/uploads\/2026\/02\/wechat_image_9.jpg 600w, https:\/\/www.huanqiukexue.com\/wp-content\/uploads\/2026\/02\/wechat_image_9-300x179.jpg 300w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><\/figure>\n\n\n\n<p><span style=\"color: rgb(153, 153, 153); font-size: 16px; letter-spacing: 1px;\">\u6297\u4f53\u53ef\u4ee5\u540c\u65f6\u7ed3\u5408\u591a\u4e2aNMDA\u53d7\u4f53\uff0c\u8fdb\u800c\u5bfc\u81f4\u53d7\u4f53\u88ab\u795e\u7ecf\u5143\u5185\u541e\uff0c\u8fdb\u800c\u5f15\u53d1\u5404\u79cd\u4e25\u91cd\u7684\u5927\u8111\u75c7\u72b6\u3002\u56fe\u7247\u6765\u6e90\u4e8e<a target=\"_blank\" href=\"https:\/\/www.science.org\/doi\/10.1126\/sciadv.aeb4249\" rel=\"noreferrer noopener\">\u8bba\u6587<\/a><\/span><\/p>\n\n\n\n<p>\u4e00\u4e9b\u7814\u7a76\u4eba\u5458\u8fd8\u53d1\u73b0\uff0c\u6297\u4f53\u8fd8\u4f1a\u963b\u6b62EphB2\u548cGluN2\u4e9a\u57fa\u7684\u7ed3\u5408\uff0c\u8ba9NMDAR\u65e0\u6cd5\u7a33\u5b9a\u5f85\u5728\u7a81\u89e6\u540e\u819c\u4e0a\u3002\u8fd9\u4e9b\u90fd\u4f1a\u5bfc\u81f4\u53d7\u4f53\u88ab\u62c9\u5230\u7ec6\u80de\u5185\uff0c\u8fdb\u800c\u88ab\u201c\u62a5\u5e9f\u201d\u3002<strong>\u968f\u7740\u7a81\u89e6\u540e\u819c\u4e0a\u7684\u8fd9\u79cd\u53d7\u4f53\u51cf\u5c11\uff0c\u795e\u7ecf\u4fe1\u53f7\u7684\u4f20\u9012\u6548\u7387\u4f1a\u660e\u663e\u964d\u4f4e\uff0c\u7a81\u89e6\u7684\u53ef\u5851\u6027\u4e5f\u4f1a\u4e25\u91cd\u53d7\u635f\uff0c\u800c\u5404\u79cd\u75c7\u72b6\u4e5f\u4f1a\u9646\u7eed\u51fa\u73b0<\/strong>\u3002<\/p>\n\n\n\n<p>\u8be5\u7814\u7a76\u7684\u5171\u540c\u4f5c\u8005\u3001\u795e\u7ecf\u79d1\u533b\u751fGary Westbrook\u8868\u793a\uff0c\u8fd9\u9879\u53d1\u73b0\u6216\u80fd\u4e3a\u5f00\u53d1\u4e00\u79cd\u4e13\u95e8\u9488\u5bf9\u8fd9\u4e2a\u81f4\u75c5\u4f4d\u70b9\u7684\u836f\u7269\u94fa\u5e73\u9053\u8def\u3002\u4ed6\u8fdb\u4e00\u6b65\u6307\u51fa\uff0c\u76ee\u524d\u9488\u5bf9\u8fd9\u79cd\u75be\u75c5\u7684\u76f8\u5173\u514d\u75ab\u6291\u5236\u7597\u6cd5\u5e76\u975e\u603b\u662f\u6709\u6548\uff0c\u4e00\u65e6\u514d\u75ab\u6291\u5236\u6cbb\u7597\u51cf\u5c11\uff0c\u8fd9\u79cd\u75be\u75c5\u8fd8\u6709\u53ef\u80fd\u590d\u53d1\uff0c\u6982\u7387\u4e3a12%\uff5e25%\uff0c\u56e0\u6b64\u6211\u4eec\u786e\u5b9e\u9700\u8981\u4e00\u4e9b\u66f4\u5177\u4f53\u7684\u7597\u6cd5\u3002<\/p>\n\n\n\n<p>\u4ece\u6cbb\u7597\u4e4b\u4e2d\u5eb7\u590d\u540e\uff0c\u82cf\u73ca\u5a1c\u00b7\u5361\u54c8\u5170\u91cd\u65b0\u5207\u6362\u56de\u4e86\u4e00\u4e2a\u8bb0\u8005\u7684\u8eab\u4efd\uff0c\u901a\u8fc7\u6536\u96c6\u6765\u81ea\u7236\u6bcd\u3001\u7537\u53cb\u4ee5\u53ca\u533b\u62a4\u4eba\u5458\u7b49\u7684\u4fe1\u606f\uff0c\u5979\u64b0\u5199\u4e86\u5173\u4e8e\u81ea\u5df1\u60a3\u75c5\u7684\u56de\u5fc6\u5f55\uff1a\u300a\u71c3\u70e7\u7684\u5927\u8111:\u6211\u53d1\u75af\u7684\u4e00\u4e2a\u6708\u300b\uff08<em>Brain on Fire: My Month of Madness<\/em>\uff09\u3002\u968f\u7740\u8fd9\u672c\u4e66\u7684\u7545\u9500\uff0c\u8fd9\u79cd\u7f55\u89c1\u7684\u81ea\u8eab\u514d\u75ab\u6027\u5927\u8111\u708e\u75c7\u4e5f\u9010\u6e10\u4e3a\u4eba\u4eec\u6240\u77e5\u3002<\/p>\n\n\n\n<p>\u8fd9\u79cd\u75c5\u4e3b\u8981\u5f71\u54cd\u5e74\u8f7b\u4eba\uff0c\u800c\u4e14\u770b\u8d77\u6765\u5f88\u201c\u90aa\u6076\u201d\u3002\u5979\u5199\u9053\uff0c\u5728\u4e0d\u4e86\u89e3\u5185\u60c5\u7684\u4eba\u770b\u6765\uff0c\u5b83\u201c\u5145\u6ee1\u6076\u610f\uff0c\u60a3\u75c5\u7684\u4eba\u5c31\u50cf\u662f\u7a81\u7136\u88ab\u9644\u8eab\uff0c\u53d8\u6210\u4e86\u5982\u540c\u6076\u9b54\u822c\u7684\u751f\u7269\u3002\u201d \u5979\u8fd8\u63d0\u9053\uff0c\u5979\u7684\u7537\u53cb\u201c\u518d\u4e5f\u4e0d\u6562\u770b \u300a\u9a71\u9b54\u4eba\u300b\u4e86\u201d\u3002\u56e0\u4e3a\u90a3\u90e8\u7535\u5f71\u4e2d\u7684\u753b\u9762\u8ba9\u4ed6\u89c9\u5f97\u592a\u903c\u771f\u4e86\uff0c\u4f1a\u8ba9\u4ed6\u611f\u5230\u4e0d\u5b89\u3002<\/p>\n\n\n\n<span style=\"color: rgb(153, 153, 153); font-size: 16px; letter-spacing: 1px;\">\u53c2\u8003\u94fe\u63a5\uff1a<br>\nhttps:\/\/www.eurekalert.org\/news-releases\/1112385<br>\nhttps:\/\/nypost.com\/2009\/10\/04\/my-mysterious-lost-month-of-madness\/<br>\nhttps:\/\/www.theguardian.com\/books\/2013\/jan\/13\/susannah-cahalan-brain-fire-interview<br>\nhttps:\/\/link.springer.com\/article\/10.1186\/s41983-022-00512-7?<br>\nhttps:\/\/pubmed.ncbi.nlm.nih.gov\/40041640\/<br>\nhttps:\/\/www.mdpi.com\/2076-3425\/15\/5\/518<\/span>\n","protected":false},"excerpt":{"rendered":"<p>\u5f53\u5927\u8111\u7a81\u7136\u5931\u63a7\u2026\u2026<\/p>\n","protected":false},"author":3,"featured_media":3679,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8,5],"tags":[],"class_list":["post-3678","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lead","category-health"],"_links":{"self":[{"href":"https:\/\/www.huanqiukexue.com\/index.php?rest_route=\/wp\/v2\/posts\/3678","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.huanqiukexue.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.huanqiukexue.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.huanqiukexue.com\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.huanqiukexue.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3678"}],"version-history":[{"count":1,"href":"https:\/\/www.huanqiukexue.com\/index.php?rest_route=\/wp\/v2\/posts\/3678\/revisions"}],"predecessor-version":[{"id":3684,"href":"https:\/\/www.huanqiukexue.com\/index.php?rest_route=\/wp\/v2\/posts\/3678\/revisions\/3684"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.huanqiukexue.com\/index.php?rest_route=\/wp\/v2\/media\/3679"}],"wp:attachment":[{"href":"https:\/\/www.huanqiukexue.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3678"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.huanqiukexue.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3678"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.huanqiukexue.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3678"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}