{"id":618,"date":"2024-03-06T22:00:00","date_gmt":"2024-03-06T14:00:00","guid":{"rendered":"https:\/\/www.huanqiukexue.com\/?p=618"},"modified":"2024-03-07T16:53:26","modified_gmt":"2024-03-07T08:53:26","slug":"%e6%8a%8a%e4%ba%ba%e3%80%81%e7%99%8c%e7%97%87%e5%92%8c%e7%97%85%e6%af%92%e6%94%be%e4%b8%80%e8%b5%b7%ef%bc%8c%e8%b0%81%e4%bc%9a%e5%85%88%e6%ad%bb%ef%bc%9f%e7%ad%94%e6%a1%88%e4%b8%8d%e4%b8%80%e5%ae%9a","status":"publish","type":"post","link":"https:\/\/www.huanqiukexue.com\/?p=618","title":{"rendered":"\u628a\u4eba\u3001\u764c\u75c7\u548c\u75c5\u6bd2\u653e\u4e00\u8d77\uff0c\u8c01\u4f1a\u5148\u6b7b\uff1f\u7b54\u6848\u4e0d\u4e00\u5b9a\u662f\u4eba"},"content":{"rendered":"
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\u5be8\u5361\u75c5\u6bd2\uff08\u56fe\u7247\u6765\u6e90\uff1aCDC\/ Cynthia Goldsmith – Public Domain\uff09<\/span><\/figcaption><\/figure>\n<\/div>\n\n\n
\u764c\u7ec6\u80de\uff1a\u5bf9\u5185\u6211\u6a2a\u884c\u9738\u9053\uff0c\u5bf9\u5916\u6211\u8dea\u5730\u6c42\u9976\u3002<\/span><\/section>\n\n\n\n
\u64b0\u6587 | \u51ac\u9e22
\u5ba1\u6821 | clefable

<\/strong>\n\n\n\n

\u4eba\u7c7b\u5bfb\u6c42\u764c\u75c7\u7684\u89e3\u836f\uff0c\u5df2\u7ecf\u6709\u6570\u4e2a\u4e16\u7eaa\u4e86\u3002\u5c3d\u7ba1\u5316\u7597\u3001\u653e\u7597\u7b49\u65b9\u6cd5\u5df2\u662f\u73b0\u4eca\u6700\u4e3b\u6d41\u7684\u7597\u6cd5\uff0c\u4f46\u79d1\u5b66\u5bb6\u4ecd\u7136\u5728\u4e0d\u505c\u5730\u5bfb\u627e\u65b0\u7684\u65b9\u5411\u3002\u6bd4\u5982\u5728\u4e0a\u4e2a\u6708\u53d1\u8868\u7684\u4e00\u9879\u7814\u7a76\u4e2d\uff0c\u7814\u7a76\u8005\u8bd5\u56fe\u5728\u5c0f\u9f20\u4f53\u5185\uff0c\u7528\u4e00\u79cd\u9887\u6709\u540d\u6c14\u7684\u75c5\u6bd2\u2014\u2014\u5be8\u5361\u75c5\u6bd2\uff08Zika virus\uff09\uff0c\u53bb\u653b\u51fb\u4e00\u79cd\u81f4\u6b7b\u7387\u6781\u9ad8\u7684\u4eba\u7c7b\u80bf\u7624\u2014\u2014\u795e\u7ecf\u6bcd\u7ec6\u80de\u7624\uff08neuroblastoma\uff09\uff0c\u7ed3\u679c\u5be8\u5361\u75c5\u6bd2\u8fd1\u4e4e\u5b8c\u5168\u6e05\u9664\u4e86\u79fb\u690d\u5230\u5c0f\u9f20\u4f53\u5185\u7684\u4eba\u7c7b\u795e\u7ecf\u6bcd\u7ec6\u80de\u7624\uff0c\u6ca1\u6709\u590d\u53d1\u8ff9\u8c61\uff0c\u800c\u4e14\u6ca1\u6709\u5bf9\u5c0f\u9f20\u9020\u6210\u4e0d\u826f\u5f71\u54cd<\/strong>\u3002<\/p>\n\n\n

\n
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\u5be8\u5361\u75c5\u6bd2\uff08\u56fe\u7247\u6765\u6e90\uff1aManuel Almagro Rivas – CC BY-SA 4.0\uff09<\/span><\/figcaption><\/figure>\n<\/div>\n\n\n



\u201c\u5723\u4f69\u91cc\u683c\u6797\u80bf\u7624\u201d<\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/span><\/mark><\/strong><\/p>\n\n\n\n

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\u8fd9\u79cd\u73b0\u8c61\u88ab\u79f0\u4e3a\u201c\u5723\u4f69\u91cc\u683c\u6797\u80bf\u7624\u201d\uff08Saint Peregrine tumor\uff09<\/strong>\uff0c\u6765\u6e90\u4e8e\u610f\u5927\u5229\u7267\u5e08\u4f69\u91cc\u683c\u6797\u00b7\u62c9\u9f50\u5965\u897f\uff08Peregrine Laziosi\uff09\u7684\u7ecf\u5386\u3002\u4ed6\u751f\u6d3b\u572813\u4e16\u7eaa\uff0c\u66fe\u60a3\u817f\u90e8\u764c\u75c7\uff0c\u5728\u9884\u5b9a\u7684\u622a\u80a2\u624b\u672f\u524d\u4ed6\u4e0d\u5e78\u53c8\u906d\u53d7\u4e86\u611f\u67d3\uff0c\u968f\u540e\u764c\u75c7\u7adf\u5b8c\u5168\u7f13\u89e3\u4e86\u3002\u56e0\u4e3a\u8fd9\u4e00\u7ecf\u5386\uff0c\u4ed6\u5728\u5f53\u65f6\u88ab\u5c0a\u79f0\u4e3a\u201c\u764c\u75c7\u60a3\u8005\u7684\u5b88\u62a4\u795e\u201d\u3002<\/p>\n\n\n\n

\u5728\u66f4\u8fd1\u4e00\u70b9\u7684\u65f6\u95f4\uff0c\u6bd4\u598218\u4e16\u7eaa\u521d\u671f\uff0c\u4e00\u4f4d\u6cd5\u56fd\u7684\u5916\u79d1\u533b\u751f\u66fe\u62a5\u9053\u4e86\u4e00\u4e2a\u4e73\u817a\u764c\u60a3\u8005\u7684\u7ecf\u5386\uff0c\u5728\u8fd9\u4f4d\u60a3\u8005\u7684\u80bf\u7624\u90e8\u4f4d\u51fa\u73b0\u4e86\u4e25\u91cd\u708e\u75c7\u548c\u574f\u75bd\u540e\uff0c\u764c\u75c7\u5f00\u59cb\u7f13\u89e3\u4e86<\/strong>\u3002\u540c\u4e00\u65f6\u671f\uff0c\u4e00\u4f4d\u6765\u81ea\u6ce2\u5e0c\u7c73\u4e9a\u7684\u89e3\u5256\u5b66\u5bb6\u62a5\u9053\u4e86\u53e6\u4e00\u4f4d\u4e73\u817a\u764c\u60a3\u8005\u76f8\u4f3c\u7684\u7ecf\u5386\uff0c\u8be5\u60a3\u8005\u7531\u4e8e\u759f\u75be\u53d1\u70e7\u4e09\u65e5\u4e4b\u540e\uff0c\u80bf\u7624\u5f00\u59cb\u6d88\u9000<\/strong>\u3002\u8fd9\u4e9b\u53d1\u73b0\u90fd\u8ba9\u5f53\u65f6\u7684\u533b\u751f\u4eec\u5f00\u59cb\u5c1d\u8bd5\u7528\u7ec6\u83cc\u6216\u75c5\u6bd2\u7f13\u89e3\u764c\u75c7\u7684\u7597\u6cd5\u3002<\/p>\n\n\n\n

1868\u5e74\uff0c\u4e00\u4f4d\u764c\u75c7\u60a3\u8005\u5728\u63a5\u79cd\u5316\u8113\u6027\u94fe\u7403\u83cc\uff08Streptococcus pyogenes<\/em>\uff09\u540e\uff0c\u53d1\u4e86\u4e00\u573a\u9ad8\u70e7\uff0c\u968f\u540e\u80bf\u7624\u4f53\u79ef\u660e\u663e\u7f29\u5c0f\u3002\u8fd9\u542f\u53d1\u4e86\u4e00\u4f4d\u53eb\u505a\u5a01\u5ec9\u00b7\u79d1\u83b1\uff08William Coley\uff09\u7684\u533b\u751f\uff0c\u4ed6\u5c06\u706d\u6d3b\u7684\u5316\u8113\u6027\u94fe\u7403\u83cc\u548c\u9ecf\u8d28\u6c99\u96f7\u83cc\uff08serratia marcescens<\/em>\uff09\u6df7\u5408\u5236\u6210\u4e86\u4e00\u79cd\u201c\u79d1\u83b1\u6bd2\u7d20\u201d\uff0c\u53ef\u4ee5\u5728\u4e0d\u5f15\u8d77\u611f\u67d3\u7684\u60c5\u51b5\u4e0b\u6cbb\u7597\u764c\u75c7\uff0c\u636e\u79f0\u60a3\u8005\u7684\u5b58\u6d3b\u7387\u9ad8\u4e8e70%<\/strong>\u2014\u2014\u4e0d\u8fc7\u540e\u6765\u7684\u79d1\u5b66\u5bb6\u5bf9\u8fd9\u4e2a\u6570\u636e\u6301\u6000\u7591\u6001\u5ea6\uff0c\u56e0\u4e3a\u79d1\u83b1\u7684\u6837\u672c\u91cf\u5f88\u5c11\uff0c\u800c\u4e14\u7edf\u8ba1\u7ed3\u679c\u5f88\u53ef\u80fd\u5b58\u5728\u9009\u62e9\u504f\u5dee\u3002<\/p>\n\n\n\n

\u540e\u6765\uff0c\u53c8\u6709\u8bb8\u591a\u7c7b\u4f3c\u201c\u5723\u4f69\u91cc\u683c\u6797\u80bf\u7624\u201d\u7684\u73b0\u8c61\u88ab\u8bb0\u5f55\u4e86\u4e0b\u6765\u30021896\u5e74\uff0c\u4e00\u4f4d42\u5c81\u5973\u6027\u5728\u60a3\u9ad3\u7ec6\u80de\u6027\u767d\u8840\u75c5\u540e\uff0c\u809d\u810f\u548c\u813e\u810f\u663e\u8457\u589e\u5927\uff0c\u767d\u7ec6\u80de\u6570\u91cf\u4e25\u91cd\u5347\u9ad8\uff0c\u4f46\u5728\u7ecf\u5386\u4e86\u4e00\u6b21\u7591\u4f3c\u6d41\u611f\u7684\u611f\u67d3\u540e\uff0c\u809d\u810f\u548c\u813e\u810f\u6062\u590d\u5230\u4e86\u6b63\u5e38\u5927\u5c0f\uff0c\u767d\u7ec6\u80de\u6570\u91cf\u4e0b\u964d\u4e8670\u591a\u500d<\/strong>\u3002\u7c7b\u4f3c\u7684\uff0c\u53e6\u4e00\u4f4d\u60a3\u6dcb\u5df4\u7ec6\u80de\u6027\u767d\u8840\u75c5\u76844\u5c81\u7537\u5b69\uff0c\u5728\u51fa\u73b0\u6c34\u75d8\u75c7\u72b6\u7684\u51e0\u5929\u5185\uff0c\u589e\u5927\u7684\u813e\u810f\u548c\u809d\u810f\u6062\u590d\u5230\u6b63\u5e38\u5927\u5c0f\uff0c\u767d\u7ec6\u80de\u6570\u91cf\u4e0b\u964d\u81f3\u6b63\u5e38\u503c\uff0c\u8840\u5c0f\u677f\u548c\u8840\u7ea2\u86cb\u767d\u663e\u8457\u589e\u52a0\uff0c\u75c5\u60c5\u5f97\u5230\u7f13\u89e3\u3002\u4e0d\u8fc7\u8fd9\u79cd\u7f13\u89e3\u4ec5\u6301\u7eed\u4e86\u4e00\u4e2a\u6708\uff0c\u968f\u540e\u767d\u8840\u75c5\u75c7\u72b6\u6062\u590d\uff0c\u5e76\u6700\u7ec8\u5e26\u8d70\u4e86\u8fd9\u4f4d\u5c0f\u7537\u5b69\u7684\u751f\u547d<\/strong>\u3002<\/p>\n\n\n

\n
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\u56fe\u7247\u6765\u6e90\uff1aDALL\u00b7E 3<\/span><\/figcaption><\/figure>\n<\/div>\n\n\n



\u6eb6\u7624\u75c5\u6bd2<\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/span><\/mark><\/strong><\/p>\n\n\n\n

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1949\u5e74\uff0c\u7814\u7a76\u8005\u8ba9\u4e00\u4e9b\u60a3\u6709\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff08Hodgkin lymphoma\uff09\u7684\u60a3\u8005\u4e3b\u52a8\u611f\u67d3\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff0c\u5176\u4e2d\u4e00\u4e9b\u60a3\u8005\u51fa\u73b0\u4e86\u7f13\u89e3\u30021952\u5e74\uff0c\u51e0\u9879\u4e34\u5e8a\u8bd5\u9a8c\u8bc1\u660e\u897f\u5c3c\u7f57\u75c5\u6bd2\uff08West Nile virus\uff09\u80fd\u591f\u5728\u764c\u7ec6\u80de\u4e2d\u590d\u5236\uff0c\u4f46\u795e\u7ecf\u6bd2\u6027\u662f\u4e00\u4e2a\u76f8\u5173\u7684\u526f\u4f5c\u7528\u3002\u968f\u540e\u53c8\u6709\u4e00\u7cfb\u5217\u9488\u5bf9\u4e0d\u540c\u75c5\u6bd2\u7684\u6eb6\u7624\u80fd\u529b\u6d4b\u8bd5\uff0c\u5305\u62ec\u817a\u75c5\u6bd2\u548c\u75b1\u75b9\u75c5\u6bd2\u7b49\u3002\u4f46\u8fd9\u4e9b\u7814\u7a76\u90fd\u4e0d\u80fd\u4fdd\u8bc1\u8fd9\u4e9b\u6eb6\u7624\u75c5\u6bd2\u5177\u6709\u6cbb\u7597\u764c\u75c7\u7684\u80fd\u529b\uff0c\u56e0\u4e3a\u5b83\u4eec\u901a\u5e38\u5b58\u5728\u5404\u79cd\u526f\u4f5c\u7528\uff0c\u8fd8\u53ef\u80fd\u56e0\u6b64\u5bfc\u81f4\u60a3\u8005\u6b7b\u4ea1<\/strong>\u2014\u2014\u65e2\u4e0d\u80fd\u4fdd\u8bc1\u7597\u6548\uff0c\u53c8\u7f3a\u4e4f\u5b89\u5168\u6027\u3002<\/p>\n\n\n\n

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\n
\"\"
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\u5be8\u5361\u75c5\u6bd2\u7684\u8fd9\u79cd\u7279\u5f02\u6027\u6e05\u9664\u764c\u7ec6\u80de\u7684\u80fd\u529b\u4e0d\u4ec5\u4f53\u73b0\u5728\u4e0e\u795e\u7ecf\u6bcd\u7ec6\u80de\u7624\u7684\u6218\u6597\u4e2d\u3002\u57282017\u5e74\u7684\u4e00\u9879\u7814\u7a76\u4e2d\uff0c\u7814\u7a76\u8005\u5728\u4f53\u5916\u7528\u5be8\u5361\u75c5\u6bd2\u653b\u51fb\u4eba\u7c7b\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624<\/strong>\uff08glioblastoma\uff0c\u4e00\u79cd\u5e38\u89c1\u8111\u90e8\u80bf\u7624\uff0c\u60a3\u8005\u5b58\u6d3b\u4e2d\u4f4d\u6570\u5c0f\u4e8e\u4e24\u5e74\uff09\u7ec4\u7ec7\u548c\u7528\u4eba\u7c7b\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u57f9\u80b2\u7684\u7c7b\u5668\u5b98\uff0c\u7ed3\u679c\u89c2\u5bdf\u5230\u4e86\u5be8\u5361\u75c5\u6bd2\u611f\u67d3\u5e76\u6740\u6b7b\u8fd9\u4e9b\u764c\u7ec6\u80de\uff0c\u6291\u5236\u80bf\u7624\u7684\u589e\u957f<\/strong>\u3002\u4ed6\u4eec\u8fd8\u53d1\u73b0\uff0c\u6ce8\u5c04\u5be8\u5361\u75c5\u6bd2\u540e\u3002\u79fb\u690d\u4e86\u4eba\u7c7b\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u7684\u5c0f\u9f20\u9884\u671f\u5bff\u547d\u66f4\u957f\u4e86\u3002<\/p>\n\n\n

\n
\"\"
\u5be8\u5361\u75c5\u6bd2\u6740\u6b7b\u5c0f\u9f20\u5927\u8111\u4e2d\u7684\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u7ec6\u80de\uff08\u56fe\u7247\u6765\u6e90\uff1aKaid et al, 2018\uff09<\/span><\/figcaption><\/figure>\n<\/div>\n\n\n

\u968f\u540e\uff0c\u57282018\u5e74\u7684\u53e6\u4e00\u9879\u7814\u7a76\u4e2d\uff0c\u7814\u7a76\u8005\u5411\u79fb\u690d\u4e86\u4eba\u7c7b\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u80bf\u7624<\/strong>\uff08\u7531\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u764c\u53d8\u4ea7\u751f\u7684\u4e00\u5927\u7c7b\u80bf\u7624\uff0c\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u4e5f\u662f\u5176\u4e2d\u4e00\u79cd\uff09\u7684\u5c0f\u9f20\u6ce8\u5c04\u5be8\u5361\u75c5\u6bd2\u540e\uff0c\u53d1\u73b0\u5c0f\u9f20\u5b58\u6d3b\u65f6\u95f4\u589e\u5f3a\u4e86\uff0c\u80bf\u7624\u8d1f\u62c5\u51cf\u8f7b\u4e86\uff0c\u764c\u7ec6\u80de\u6269\u6563\u4e5f\u51cf\u5c11\u4e86\uff0c\u5c0f\u9f20\u75c5\u60c5\u5f97\u5230\u4e86\u7f13\u89e3\u3002\u800c\u4e14\u5be8\u5361\u75c5\u6bd2\u8c8c\u4f3c\u53ea\u653b\u51fb\u764c\u7ec6\u80de\uff0c\u800c\u5b83\u7684\u4eb2\u621a\u897f\u5c3c\u7f57\u75c5\u6bd2\uff08\u4e0e\u5be8\u5361\u75c5\u6bd2\u540c\u4e3a\u9ec4\u75c5\u6bd2\u5c5e\uff09\u4e0d\u4ec5\u653b\u51fb\u764c\u7ec6\u80de\uff0c\u8fd8\u4f1a\u653b\u51fb\u6b63\u5e38\u795e\u7ecf\u7ec6\u80de\u3002<\/strong><\/p>\n\n\n\n

\u7814\u7a76\u8005\u53d1\u73b0\uff0c\u5be8\u5361\u75c5\u6bd2\u653b\u51fb\u7684\u4e3b\u8981\u662f\u8868\u8fbeCD24\u86cb\u767d\u7684\u764c\u7ec6\u80de<\/strong>\uff0cCD24\u7684\u5b58\u5728\u901a\u5e38\u610f\u5473\u7740\u7ec6\u80de\u5904\u4e8e\u5206\u5316\u72b6\u6001\uff0c\u800c\u80bf\u7624\u4e2d\u9ad8\u5ea6\u8868\u8fbe\u7684CD24\u901a\u5e38\u88ab\u8ba4\u4e3a\u662f\u80bf\u7624\u589e\u6b96\u7684\u9a71\u52a8\u56e0\u7d20\u4ee5\u53ca\u591a\u79cd\u764c\u75c7\u4e0d\u826f\u9884\u540e\u7684\u9884\u6d4b\u56e0\u5b50\u3002\u6362\u53e5\u8bdd\u8bf4\uff0c\u75c5\u6bd2\u4e3b\u8981\u653b\u51fb\u5177\u6709\u5206\u5316\u80fd\u529b\u7684\u764c\u75c7\u5e72\u7ec6\u80de\uff0c\u800c\u8fd9\u7c7b\u764c\u7ec6\u80de\u7684\u5b58\u5728\u6070\u597d\u662f\u6076\u6027\u80bf\u7624\u96be\u4ee5\u88ab\u6e05\u9664\u7684\u91cd\u8981\u539f\u56e0\u4e4b\u4e00<\/strong>\u3002<\/p>\n\n\n\n

\u7814\u7a76\u8005\u8ba4\u4e3a\uff0c\u6b64\u540e\uff0c\u5bf9\u4e8e\u5176\u5b83\u4f1a\u8868\u8fbeCD24\u86cb\u767d\u7684\u80bf\u7624\uff0c\u5be8\u5361\u75c5\u6bd2\u6216\u8bb8\u4e5f\u80fd\u53d1\u6325\u4f5c\u7528\uff0c\u5be8\u5361\u75c5\u6bd2\u7684\u5e94\u7528\u6216\u6709\u6f5c\u529b\u6210\u4e3a\u4e00\u79cd\u65b0\u7684\u764c\u75c7\u7597\u6cd5\u3002\u5e0c\u671b\u4e0d\u4e45\u4e4b\u540e\uff0c\u4f1a\u51fa\u73b0\u5168\u65b0\u7684\u57fa\u4e8e\u5be8\u5361\u75c5\u6bd2\u7684\u764c\u75c7\u7597\u6cd5\uff0c\u4e3a\u764c\u75c7\u60a3\u8005\u5e26\u6765\u65b0\u7684\u798f\u97f3\u5427\u3002<\/p>\n\n\n\n
\u53c2\u8003\u94fe\u63a5\uff1a
https:\/\/aacrjournals.org\/cancerrescommun\/article\/4\/1\/65\/732575\/The-Oncolytic-Activity-of-Zika-Viral-Therapy-in
https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0300908422002759
https:\/\/www.cell.com\/molecular-therapy-family\/molecular-therapy\/fulltext\/S1525-0016(16)31331-4
https:\/\/aacrjournals.org\/cancerres\/article\/78\/12\/3363\/627779\/Zika-Virus-Selectively-Kills-Aggressive-Human
https:\/\/rupress.org\/jem\/article-standard\/214\/10\/2843\/42255\/Zika-virus-has-oncolytic-activity-against
https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/zika-virus
https:\/\/www.cancer.org\/cancer\/types\/neuroblastoma\/about\/what-is-neuroblastoma.html
https:\/\/www.livescience.com\/health\/cancer\/zika-virus-could-potentially-treat-cancer-another-early-study-hints
https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0232858
https:\/\/www.cell.com\/cell-stem-cell\/fulltext\/S1934-5909(16)30084-4
https:\/\/www.cell.com\/cell-stem-cell\/fulltext\/S1934-5909(16)00106-5
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